Departments of Endocrinology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Departments of Endocrinology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Endocr Pract. 2021 Jul;27(7):710-715. doi: 10.1016/j.eprac.2020.12.012. Epub 2020 Dec 29.
Primary hyperparathyroidism (PHPT) is a common endocrine disorder in women which becomes more prevalent after menopause. In this study, we compared the demographic, clinical, and biochemical variables between premenopausal (pre-M) and postmenopausal (post-M) women with PHPT.
A retrospective analysis (from 2005 to 2019) of enrolled women PHPT patients from an online Indian PHPT registry.
Of the women with PHPT, 232 and 122 were pre-M and post-M, respectively. The number of post-M PHPT cases registered had a 3.3-fold increase in 2015-2019 from 2005-2009 compared with only a 2.5-fold increase in pre-M cases in the same duration. The majority were symptomatic (90%), although pre-M had a higher proportion of symptomatic than post-M (92% vs 85%; P = .04). Pre-M women showed more prevalence of osteitis fibrosa cystica than post-M women (28% vs 13%; P = .03), although hypertension and gallstone disease were seen more frequently in post-M PHPT women. Pre-M women had a significantly higher median PTH (403 vs 246 pg/mL; P = .02) and median alkaline phosphatase (202 vs 145 pg/mL; P = .02) than post-M women, and vitamin D deficiency was more common in pre-M women (58% vs 45%; P = .03). Gland localization, tumor weight, and disease cure rates did not differ according to menopausal status.
PHPT was more prevalent in pre-M women, although the number of post-M cases had significantly increased in the last 10 years. Pre-M women had generally more severe clinical and biochemical variables than post-M PHPT women.
原发性甲状旁腺功能亢进症（PHPT）是一种常见的女性内分泌疾病，绝经后更为常见。本研究比较了绝经前（pre-M）和绝经后（post-M）PHPT 女性的人口统计学、临床和生化变量。
对来自印度 PHPT 在线注册的 PHPT 女性患者进行回顾性分析（2005 年至 2019 年）。
在 PHPT 女性中，分别有 232 例和 122 例为 pre-M 和 post-M。与 pre-M 病例同期相比，2015-2019 年 post-M PHPT 病例的登记数量增加了 3.3 倍，而同期增加了 2.5 倍。大多数患者有症状（90%），尽管 pre-M 的症状比例高于 post-M（92%比 85%；P=0.04）。pre-M 女性比 post-M 女性更常见纤维囊性骨炎（28%比 13%；P=0.03），而高血压和胆囊疾病在 post-M PHPT 女性中更为常见。pre-M 女性的中位 PTH（403 比 246 pg/mL；P=0.02）和中位碱性磷酸酶（202 比 145 pg/mL；P=0.02）明显高于 post-M 女性，pre-M 女性维生素 D 缺乏更为常见（58%比 45%；P=0.03）。根据绝经状态，腺体定位、肿瘤重量和疾病治愈率无差异。
尽管绝经后 PHPT 病例在过去 10 年中显著增加，但 PHPT 在绝经前女性中更为常见。与 post-M PHPT 女性相比，pre-M 女性的临床和生化变量通常更为严重。
