Buenestado-Serrano Sergio, Recio Raúl, Sola Campoy Pedro J, Catalán Pilar, Folgueira M Dolores, Villa Jennifer, Muñoz Gallego Irene, de la Cueva Víctor Manuel, Meléndez M Angeles, Andrés Zayas Cristina, Losa-García Juan E, Goyanes M José, Fraile Torres Arturo, Von Wermitz Andres, Fradejas-Villajos Isabel, Del Arco Carmen, Campelo-Gutiérrez Carolina, González Bodi Sara, López-Wolf Daniel, Iglesias-Franco Higinio, Pérez-Lago Laura, Arce Arnaez Araceli, Rodriguez Baena Elena, Ordobas Gavin María, Muñoz Patricia, Delgado Rafael, Cardeñoso Laura, Viedma Esther, García de Viedma Darío
Servicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Spain; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
Servicio de Microbiología 12 de Octubre General University Hospital, Spain; Instituto de Investigación Sanitaria 12 de Octubre, Madrid, Spain.
Enferm Infecc Microbiol Clin (Engl Ed). 2021 Feb 19;40(10):546-9. doi: 10.1016/j.eimc.2021.02.006.
A newly identified SARS-CoV-2 variant, VOC202012/01 originating lineage B.1.1.7, recently emerged in the United Kingdom. The rapid spread in the UK of this new variant has caused other countries to be vigilant.
We based our initial screening of B.1.1.7 on the dropout of the S gene signal in the TaqPath assay, caused by the 69/70 deletion. Subsequently, we confirmed the B.1.1.7 candidates by whole genome sequencing.
We describe the first three imported cases of this variant from London to Madrid, subsequent post-arrival household transmission to three relatives, and the two first cases without epidemiological links to UK. One case required hospitalization. In all cases, drop-out of gene S was correctly associated to the B.1.1.7 variant, as all the corresponding sequences carried the 17 lineage-marker mutations.
The first identifications of the SARS-CoV-2 B.1.1.7 variant in Spain indicate the role of independent introductions from the UK coexisting with post-arrival transmission in the community, since the early steps of this new variant in our country.
一种新发现的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）变体，即源自B.1.1.7谱系的VOC202012/01，最近在英国出现。这种新变体在英国的迅速传播已引起其他国家的警惕。
我们最初对B.1.1.7的筛查基于TaqPath检测中S基因信号的缺失，该缺失由69/70位缺失引起。随后，我们通过全基因组测序确认了B.1.1.7候选毒株。
我们描述了该变体从伦敦输入马德里的前三例病例，随后在抵达后家庭传播给三名亲属，以及另外两例与英国无流行病学关联的首例病例。其中一例需要住院治疗。在所有病例中，基因S的缺失均与B.1.1.7变体正确相关，因为所有相应序列均携带17个谱系标记突变。
在西班牙首次发现SARS-CoV-2 B.1.1.7变体，表明自我国出现这种新变体的早期阶段以来，来自英国的独立输入病例与抵达后社区传播并存的情况。
