Yang Zhen, Zhang Shuo, Tang Yu-Ping, Zhang Sai, Xu Ding-Qiao, Yue Shi-Jun, Liu Qi-Ling
1Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, and State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), and Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, and Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xi'an, Shaanxi, China.
2School of Public Health, Shaanxi University of Chinese Medicine, Xi'an, Shaanxi, China.
Aging Dis. 2022 Apr 1;13(2):402-422. doi: 10.14336/AD.2021.1210. eCollection 2022 Apr.
In addition to the rapid, global spread of SARS-CoV-2, new and comparatively more contagious variants are of considerable concern. These emerging mutations have become a threat to the global public health, creating COVID-19 surges in different countries. However, information on these emerging variants is limited and scattered. In this review, we discuss new variants that have emerged worldwide and identify several variants of concern, such as B.1.1.7, B.1.351, P.1, B.1.617.2 and B.1.1.529, and their basic characteristics. Other significant variants such as C.37, B.1.621, B.1.525, B.1.526, AZ.5, C.1.2, and B.1.617.1 are also discussed. This review highlights the clinical characteristics of these variants, including transmissibility, pathogenicity, susceptible population, and re-infectivity. It provides the latest information on the recent variants of SARS-CoV-2. The summary of this information will help researchers formulate reasonable strategies to curb the ongoing COVID-19 pandemic.
除了严重急性呼吸综合征冠状病毒2(SARS-CoV-2)在全球迅速传播外,新的且传染性相对更强的变种也备受关注。这些新出现的突变已对全球公共卫生构成威胁,在不同国家引发了新冠疫情的激增。然而,关于这些新出现变种的信息有限且分散。在本综述中,我们讨论了在全球出现的新变种,并确定了几个值得关注的变种,如B.1.1.7、B.1.351、P.1、B.1.617.2和B.1.1.529,以及它们的基本特征。还讨论了其他重要变种,如C.37、B.1.621、B.1.525、B.1.526、AZ.5、C.1.2和B.1.617.1。本综述突出了这些变种的临床特征,包括传播性、致病性、易感人群和再感染性。它提供了关于SARS-CoV-2近期变种的最新信息。这些信息的总结将有助于研究人员制定合理策略来遏制当前的新冠疫情大流行。