Addley Susan, Alazzam Moiad, Johnson Catherine, Soleymani Majd Hooman
Department of Gynaecology Oncology, Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, UK.
Department of Radiology, Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, UK.
BMJ Case Rep. 2021 Mar 8;14(3):e237669. doi: 10.1136/bcr-2020-237669.
Gastrointestinal stromal tumours (GISTs) are rare - and rectovaginal extragastrointestinal stromal tumours (RV-EGISTs) even rarer. We share a case of RV-EGIST, complemented by high-quality radiological and surgical images. A review of current literature pertaining to RV-EGIST is also included. Our case report highlights the diagnostic challenge presented by extragastrointestinal stromal tumours. Differentiated from overlapping pathologies only by targeted application of immunohistopathology and cytogenetics, the inclusion of RV-EGIST in the differential diagnosis of a rectovaginal tumour is essential to making this correct diagnosis. Primary surgery is the treatment of choice for RV-EGIST if complete cytoreduction can be achieved, combined with adjuvant tyrosine kinase inhibitor (TKI) therapy for those with high-risk features to further reduce rates of future recurrence.
胃肠道间质瘤（GISTs）较为罕见，而直肠阴道部胃肠道外间质瘤（RV - EGISTs）更为罕见。我们分享一例RV - EGIST病例，并辅以高质量的放射影像和手术图像。本文还纳入了对当前有关RV - EGIST文献的综述。我们的病例报告突出了胃肠道外间质瘤所带来的诊断挑战。仅通过针对性应用免疫组织病理学和细胞遗传学与重叠病变相鉴别，将RV - EGIST纳入直肠阴道部肿瘤的鉴别诊断对于做出正确诊断至关重要。如果能够实现完全细胞减灭，手术是RV - EGIST的首选治疗方法，对于具有高危特征的患者，联合辅助酪氨酸激酶抑制剂（TKI）治疗以进一步降低未来复发率。
