Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), 14558, Nuthetal, Germany.
German Center for Diabetes Research (DZD), 85764, München-Neuherberg, Germany.
Eur J Nutr. 2021 Sep;60(6):3499-3504. doi: 10.1007/s00394-021-02518-y. Epub 2021 Mar 8.
Increased animal but not plant protein intake has been associated with increased mortality in epidemiological studies in humans and with reduced lifespan in animal species. Protein intake increases the activity of the IGF-1 system which may provide a link to reduced lifespan. We, therefore, compared the effects of animal versus plant protein intake on circulating levels of IGF-1 and the IGF-binding proteins (IGFBP)-1 and IGFBP-2 over a 6-week period. Thirty seven participants with type 2 diabetes consumed isocaloric diets composed of either 30% energy (EN) animal or plant protein, 30% EN fat and 40% EN carbohydrates for 6 weeks. The participants were clinically phenotyped before and at the end of the study. Both diets induced similar and significant increases of IGF-1 which was unaffected by the different amino acid compositions of plant and animal protein. Despite improvements of insulin sensitivity and major reductions of liver fat, IGFBP2 decreased with both diets while IGFBP-1 was not altered. We conclude that animal and plant protein similarly increase IGF-1 bioavailability while improving metabolic parameters and may be regarded as equivalent in this regard.
在人体流行病学研究中，动物蛋白而非植物蛋白摄入量的增加与死亡率的增加有关，在动物物种中与寿命的缩短有关。蛋白质的摄入增加了 IGF-1 系统的活性，这可能为寿命缩短提供了一个联系。因此，我们比较了动物蛋白和植物蛋白摄入对循环 IGF-1 水平以及 IGF 结合蛋白（IGFBP）-1 和 IGFBP-2 的影响，为期 6 周。37 名 2 型糖尿病患者在 6 周内摄入等热量的饮食，其中 30%的能量来自动物或植物蛋白、30%的能量来自脂肪和 40%的能量来自碳水化合物。在研究前后对参与者进行了临床表型分析。两种饮食均导致 IGF-1 显著增加，而植物蛋白和动物蛋白的不同氨基酸组成对 IGF-1 没有影响。尽管胰岛素敏感性得到改善，肝脂肪大量减少，但两种饮食都会导致 IGFBP2 下降，而 IGFBP-1 没有改变。我们的结论是，动物蛋白和植物蛋白同样增加 IGF-1 的生物利用度，同时改善代谢参数，在这方面可以被视为等效的。
