Zheng Wei, Lai Yayu, Jin Peng, Gu Wenzhu, Zhou Qi, Wu Xiaojing
Cardiovascular Department, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
Cardiovascular Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Dis Markers. 2017;2017:1917291. doi: 10.1155/2017/1917291. Epub 2017 Feb 20.
Local IGFBP1 level was reported to affect the development of coronary artery plaque. This study investigated the association of circulating IGFBP1 level with the severity of coronary artery lesions in patients with unstable angina. In 112 consecutive patients with clinically diagnosed unstable angina, admitted from July 2014 to July 2015, we studied the correlations of circulating IGFBP1 and the severity of coronary artery disease (CAD). All patients underwent scheduled coronary angiography, and 67 cases were diagnosed with critical and 45 with noncritical CAD. Of the 67 critical CAD patients, 41 (61.19%) presented with multivessel and 26 (38.81%) with single-vessel lesions. IGFBP1 levels were higher in patients with multivessel than those with single-vessel lesions. Moreover, the IGFBP1 level was positively correlated with the GRACE score. Among clinical variables, the IGFBP1 level was correlated with HDL-C. IGFBP1 alone (cutoff 20.86 ng/ml) demonstrated a sensitivity of 0.448 and specificity of 0.933 in predicting CAD. Combination of IGFBP1 and HDL-C had a sensitivity of 0.821 and specificity of 0.800 in predicting CAD. Circulating IGFBP1 level positively correlated with the severity of CAD. IGFBP1, when combined with HDL-C, might be useful in screening for high risk CAD patients.
据报道，局部胰岛素样生长因子结合蛋白1（IGFBP1）水平会影响冠状动脉斑块的发展。本研究调查了不稳定型心绞痛患者循环IGFBP1水平与冠状动脉病变严重程度之间的关联。在2014年7月至2015年7月收治的112例临床诊断为不稳定型心绞痛的连续患者中，我们研究了循环IGFBP1与冠状动脉疾病（CAD）严重程度的相关性。所有患者均接受了常规冠状动脉造影，其中67例被诊断为重度CAD，45例为非重度CAD。在67例重度CAD患者中，41例（61.19%）表现为多支血管病变，26例（38.81%）为单支血管病变。多支血管病变患者的IGFBP1水平高于单支血管病变患者。此外，IGFBP1水平与全球急性冠状动脉事件注册（GRACE）评分呈正相关。在临床变量中，IGFBP1水平与高密度脂蛋白胆固醇（HDL-C）相关。单独的IGFBP1（临界值为20.86 ng/ml）在预测CAD方面的敏感性为0.448，特异性为0.933。IGFBP1与HDL-C联合在预测CAD方面的敏感性为0.821，特异性为0.800。循环IGFBP1水平与CAD的严重程度呈正相关。IGFBP1与HDL-C联合使用可能有助于筛查CAD高危患者。
