Department of Internal Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Curr Cardiol Rep. 2021 Mar 8;23(4):36. doi: 10.1007/s11886-021-01457-8.
The purpose of this review is to explore the evolution and outcomes of premature coronary artery disease (PCAD) while reviewing strategies for effective screening of those at high risk for developing this disease.
Premature coronary artery disease (PCAD) affects a population of patients not typically identified as high risk by current risk stratification guidelines or traditional risk calculation tools. Not only does PCAD represent a large proportion of overall cardiovascular disease, it also afflicts a population in which the rate of mortality from cardiovascular disease has plateaued despite an overall declining population-wide cardiovascular mortality rate. There is ample opportunity for behavioral change strategies, screening tools, adapted imaging modalities, and precision pharmacotherapies to be more precisely targeted toward those at highest risk for premature coronary artery disease. Premature coronary artery disease (PCAD) is pervasive and not frequently represented within contemporary risk calculation models. Providers should pursue proactive screening and aggressive risk factor modification and deploy appropriate preventative therapies in caring for younger populations.
本文旨在探讨早发冠状动脉疾病（PCAD）的演变和结局，并探讨对高危人群进行有效筛查的策略。
早发冠状动脉疾病（PCAD）影响了一大类不符合目前风险分层指南或传统风险计算工具标准的高危人群。PCAD 不仅在总体心血管疾病中占很大比例，而且在心血管疾病死亡率总体下降的情况下，其发病率仍处于停滞状态，影响着一个人群。行为改变策略、筛查工具、适应性成像模式和精准药物治疗有充分的机会更精确地针对那些发生早发冠状动脉疾病风险最高的人群。早发冠状动脉疾病（PCAD）普遍存在，并且在当代风险计算模型中并不常见。在治疗年轻人群时，医务人员应主动进行筛查和积极的危险因素干预，并使用适当的预防治疗方法。
