Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 151 Malianwa North Road, Beijing, 100193, China.
National Citrus Engineering Research Center, Citrus Research Institute, Southwest University, Chongqing, 400712, China.
Arch Virol. 2021 May;166(5):1513-1515. doi: 10.1007/s00705-021-05028-8. Epub 2021 Mar 9.
A novel virus was identified in aconite (Aconitum carmichaelii Debx.) in China by high-throughput sequencing (HTS) and tentatively named "aconite virus A" (AcVA). The genomic RNA of AcVA consists of 8,844 nucleotides, excluding the poly(A) at the 3' end. Analysis of the genomic organization of AcVA indicated that it possesses a genomic structure that is typical of carlaviruses and contains six putative open reading frames (ORFs). Pairwise analysis revealed that the replicase and coat protein of AcVA share the highest amino acid sequence identity (43.78% and 57.01%) with those of coleus vein necrosis virus (CVNV) and butterbur mosaic virus (ButMV), respectively. Based on the current classification criteria for carlaviruses, AcVA should be considered a distinct member of the genus Carlavirus.
一种新型病毒在中国乌头（Aconitum carmichaelii Debx.）中通过高通量测序（HTS）被鉴定出来，并被暂时命名为“乌头病毒 A”（AcVA）。AcVA 的基因组 RNA 由 8844 个核苷酸组成，不包括 3' 端的 poly(A)。对 AcVA 的基因组组织分析表明，它具有典型的 carlaviruses 基因组结构，包含六个假定的开放阅读框（ORFs）。序列比对分析表明，AcVA 的复制酶和外壳蛋白与 coleus vein necrosis virus（CVNV）和 butterbur mosaic virus（ButMV）的氨基酸序列同源性最高（分别为 43.78%和 57.01%）。根据 carlaviruses 的现行分类标准，AcVA 应被视为 Carlavirus 属的一个独特成员。
