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1型白细胞黏附缺陷(LAD-1)合并坏疽性脓皮病及COVID-19疫情背景下的妊娠:患者及医生的经历

Pyoderma Gangrenosum with an Underlying Leukocyte Adhesion Deficiency Type 1 (LAD-1) and Pregnancy in the Shade of COVID-19 Epidemic: A Patient and Physician Experience.

作者信息

Opalińska Aleksandra, Burdacki Adrian, Kwaśniak Konrad, Pogoda Katarzyna, Tabarkiewicz Jacek, Reich Adam

机构信息

Department of Dermatology, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszów, Poland.

Department of Hematology, Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszów, Poland.

出版信息

Dermatol Ther (Heidelb). 2021 Jun;11(3):643-653. doi: 10.1007/s13555-021-00507-x. Epub 2021 Mar 8.

Abstract

In the first part of this article, the anonymous patient diagnosed with leukocyte adhesion deficiency type 1 (LAD-1) and pyoderma gangrenosum (PG) discusses her experience of her medical history and treatment in a foreign country during her pregnancy and the coronavirus disease-19 (COVID-19) pandemic. The patient's dermatologists, immunologist, and diagnostician refer to the epidemiology, genetics, diagnosis, morphologic manifestations, including skin lesions, treatment, and prognosis in LAD-1. The patient's diagnostic and therapeutic process was discussed in the last part of this paper.

摘要

在本文的第一部分,这位被诊断患有1型白细胞黏附缺陷症(LAD-1)和坏疽性脓皮病(PG)的匿名患者讲述了她在孕期以及新型冠状病毒肺炎(COVID-19)大流行期间在国外的病史和治疗经历。患者的皮肤科医生、免疫学家和诊断医生介绍了LAD-1的流行病学、遗传学、诊断、形态学表现(包括皮肤病变)、治疗方法及预后情况。本文最后一部分讨论了该患者的诊断和治疗过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4574/8163945/27d16c7b6f40/13555_2021_507_Fig1_HTML.jpg

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