University Medical Center Utrecht, Utrecht, the Netherlands.
Catharina Hospital Eindhoven, Eindhoven, the Netherlands.
Aesthet Surg J. 2021 Jul 14;41(8):NP1000-NP1013. doi: 10.1093/asj/sjab109.
Lipofilling has become popular as a treatment to improve aging-related skin characteristics (eg, wrinkles, pigmentation spots, pores, or rosacea). Different additives such as platelet-rich plasma (PRP) or stromal vascular fraction (SVF) have been combined with lipofilling to increase the therapeutic effect of adipose-derived stromal cells (ASCs).
The aim of this study was to examine the hypothesis that mechanically isolated SVF augments the therapeutic effect of PRP-supplemented lipofilling to improve facial skin quality.
This prospective, double-blind, placebo-controlled, randomized trial was conducted between 2016 and 2019. In total, 28 female subjects were enrolled; 25 completed the follow-up. All patients received PRP-supplemented lipofilling with either mechanically isolated SVF or saline. SVF was isolated by fractionation of adipose tissue (tSVF). Results were evaluated by changes in skin elasticity and transepidermal water loss, changes in skin-aging-related features, ie, superficial spots, wrinkles, skin texture, pores, vascularity, and pigmentation, as well as patient satisfaction (FACE-Q), recovery, and number of complications up to 1 year postoperative.
The addition of tSVF to PRP-supplemented lipofilling did not improve skin elasticity, transepidermal water loss, or skin-aging-related features. No improvement in patient satisfaction with overall facial appearance or facial skin quality was seen when tSVF was added to PRP-supplemented lipofilling.
In comparison to PRP-supplemented lipofilling, PRP-supplemented lipofilling combined with tSVF does not improve facial skin quality or patient satisfaction in a healthy population. PRP-supplemented lipofilling combined with tSVF can be considered a safe procedure.
脂肪填充术已成为改善与衰老相关的皮肤特征（如皱纹、色素斑、毛孔或酒渣鼻）的一种流行治疗方法。不同的添加剂，如富含血小板的血浆（PRP）或基质血管成分（SVF）已与脂肪填充术结合使用，以增加脂肪来源的基质细胞（ASC）的治疗效果。
本研究旨在检验以下假设，即机械分离的 SVF 可增强 PRP 补充脂肪填充术改善面部皮肤质量的治疗效果。
这是一项前瞻性、双盲、安慰剂对照、随机临床试验，于 2016 年至 2019 年进行。共纳入 28 名女性受试者，25 名完成了随访。所有患者均接受 PRP 补充脂肪填充术，填充材料为 PRP 联合机械分离的 SVF 或生理盐水。SVF 通过脂肪组织的分级分离（tSVF）分离。通过皮肤弹性和经表皮水分流失的变化、皮肤老化相关特征（如浅斑点、皱纹、皮肤质地、毛孔、血管和色素沉着）的变化以及患者满意度（FACE-Q）、恢复情况和 1 年内并发症的数量来评估结果。
PRP 补充脂肪填充术联合 tSVF 并不能改善皮肤弹性和经表皮水分流失，也不能改善皮肤老化相关特征。与 PRP 补充脂肪填充术相比，在 PRP 补充脂肪填充术中加入 tSVF 并不能改善患者对整体面部外观或面部皮肤质量的满意度。
与 PRP 补充脂肪填充术相比，PRP 补充脂肪填充术联合 tSVF 并不能改善健康人群的面部皮肤质量或患者满意度。PRP 补充脂肪填充术联合 tSVF 可被视为一种安全的手术方法。
