Zhou Yi, Chen Yonglu, He Chunmao
School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.
Dalton Trans. 2021 Mar 28;50(12):4231-4236. doi: 10.1039/d1dt00395j. Epub 2021 Mar 9.
A one-pot synthetic route has been developed for the assembly of peptide Mn(i)-carbonyl bioconjugates. It allows the installation of a variety of chelating agents at the late stage, and after just one purification step the TAT-MnCO complexes can be obtained. The resulting bioconjugates showed different and tunable CO releasing kinetics upon visible light activation.
已经开发出一种用于组装肽-Mn(i)-羰基生物共轭物的一锅法合成路线。它允许在后期安装各种螯合剂，并且只需一步纯化步骤就可以得到TAT-MnCO复合物。所得的生物共轭物在可见光激活后表现出不同且可调节的CO释放动力学。
