Jimenez Jorge, Chakraborty Indranil, Dominguez Annmarie, Martinez-Gonzalez Jorge, Sameera W M Chamil, Mascharak Pradip K
Department of Chemistry and Biochemistry, University of California, Santa Cruz , Santa Cruz, California 95064, United States.
Inorg Chem. 2018 Feb 19;57(4):1766-1773. doi: 10.1021/acs.inorgchem.7b02480. Epub 2018 Feb 2.
A photoactive manganese carbonyl complex derived from dansylimidazole (Imdansyl), namely, Mn(Imdansyl)(CO)(phen) (1), has been synthesized and structurally characterized. This is the first luminescent manganese carbonyl-based photoCORM reported in the literature. This complex exhibits CO release under the exclusive control of low-power broadband visible light. The corresponding rhenium carbonyl complex, namely, Re(Imdansyl)(CO)(phen) (2), has also been reported, which is luminescent but sensitive only to UV-B (λ<315 nm) light. The entry of the manganese photoCORM into the human colorectal adenocarcinoma cells (HT-29) has been demonstrated with the aid of fluorescence microscopy. Irradiation of the photoCORM-loaded cancer cells to visible light leads to a dose-dependent apoptotic cell death.
一种源自丹磺酰咪唑（Imdansyl）的光活性羰基锰配合物，即Mn(Imdansyl)(CO)(phen)（1），已被合成并进行了结构表征。这是文献中报道的首例基于羰基锰的发光光化学一氧化碳释放剂（photoCORM）。该配合物在低功率宽带可见光的专属控制下表现出一氧化碳释放。相应的羰基铼配合物，即Re(Imdansyl)(CO)(phen)（2），也已被报道，它具有发光性，但仅对UV - B（λ<315 nm）光敏感。借助荧光显微镜已证实光化学一氧化碳释放剂锰进入人结肠直肠腺癌细胞（HT - 29）。用可见光照射负载了光化学一氧化碳释放剂的癌细胞会导致剂量依赖性的凋亡性细胞死亡。
