Post Hannah, Magnolo Nina, Böhm Markus
Klinik für Hautkrankheiten, Universitätsklinikum Münster, Von-Esmarch-Str. 58, 48149, Münster, Deutschland.
Hautarzt. 2021 Nov;72(11):992-995. doi: 10.1007/s00105-021-04784-7. Epub 2021 Mar 9.
Generalized pustular psoriasis is a rare, often relapsing and usually severe inflammatory skin disease with concomitant systemic symptoms in many cases. The disease is in part due to mutations in the gene of the interleukin-36 receptor antagonist (IL36RN) explaining the autoinflammatory nature of this condition. Here, we report on a 39-year-old pregnant woman who stopped her medication with secukinumab due to her pregnancy. Subsequently, she suffered from severe exacerbation of her disease and was admitted to our hospital. The patient had a known mutation in the IL36RN (Ser113Leu) gene. At the 33rd week of her pregnancy therapy with certolizumab was initiated and resulted in a rapid remission within a few weeks. After the patient gave birth, remission could be maintained under the given therapy with this biologic.
泛发性脓疱型银屑病是一种罕见的、常复发且通常严重的炎症性皮肤病，许多病例伴有全身症状。该疾病部分归因于白细胞介素-36受体拮抗剂（IL36RN）基因的突变，这解释了这种病症的自身炎症性质。在此，我们报告一名39岁的孕妇，她因怀孕停用了司库奇尤单抗。随后，她的病情严重加重并入住我院。该患者在IL36RN（Ser113Leu）基因存在已知突变。在她怀孕第33周时开始使用赛妥珠单抗治疗，几周内病情迅速缓解。患者分娩后，在使用这种生物制剂的既定治疗下病情缓解得以维持。
