Pogorelov Dimitrii, Tschesche Anne, Balakirski Galina, Hofmann Silke C
Center for Dermatology, Allergology and Dermatosurgery, Helios University Hospital Wuppertal, Wuppertal, DEU.
Cureus. 2024 May 7;16(5):e59832. doi: 10.7759/cureus.59832. eCollection 2024 May.
Generalized pustular psoriasis of pregnancy (GPPP) is a rare dermatological condition that significantly affects maternal health and pregnancy outcomes. The treatment of this disease might be very challenging, as only a limited number of effective therapeutic options are available. If the use of systemic drugs is considered, they should ideally effectively control the systemic inflammation without harming the fetus. Here, we report the successful treatment of a severe case of GPPP in a 28-year-old woman using the tumor necrosis factor-alpha inhibitor (TNFi) certolizumab pegol. Additionally, we review the existing literature on the use of this class of drugs for treating GPPP. To date, there are only 11 reported cases of this severe skin condition treated with a TNFi. We also discuss the pathogenesis of GPPP and the rationale behind using TNFi for its treatment.
妊娠泛发性脓疱型银屑病（GPPP）是一种罕见的皮肤病，严重影响孕产妇健康和妊娠结局。这种疾病的治疗可能极具挑战性，因为有效的治疗选择有限。如果考虑使用全身性药物，理想情况下，它们应能有效控制全身炎症而不伤害胎儿。在此，我们报告了使用肿瘤坏死因子-α抑制剂（TNFi）赛妥珠单抗成功治疗一名28岁重症GPPP女性患者的病例。此外，我们回顾了关于这类药物用于治疗GPPP的现有文献。迄今为止，仅有11例使用TNFi治疗这种严重皮肤病的报道病例。我们还讨论了GPPP的发病机制以及使用TNFi治疗的理论依据。
