He Xin-Ling, Xu Xiao-Huang, Shi Jia-Jie, Huang Mingqing, Wang Yitao, Chen Xiuping, Lu Jin-Jian
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao,China.
College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122,China.
Curr Mol Pharmacol. 2022;15(1):179-189. doi: 10.2174/1874467214666210309115105.
As one of the effective pharmacological constituents of Ginseng Radix et Rhizoma, ginsenoside Rh2 (Rh2) exerts a remarkable anticancer effect on various cancer cell lines in vitro and strongly inhibits tumor growth in vivo without severe toxicity.
This article reviewed existing evidence supporting the anticancer effects of Rh2 to classify and conclude previous and current knowledge on the mechanisms and therapeutic effects of Rh2, as well as to promote the clinical application of this natural product.
This article reviewed the anticancer efficacies and mechanisms of Rh2, including the induction of cell cycle arrest and programmed cell death, repression of metastasis, alleviation of drug resistance, and regulation of the immune system. Finally, this paper discussed the research and application prospects of Rh2.
人参皂苷Rh2（Rh2）作为人参的有效药理成分之一，在体外对多种癌细胞系具有显著的抗癌作用，且在体内能强烈抑制肿瘤生长，而无严重毒性。
本文综述支持Rh2抗癌作用的现有证据，对Rh2的作用机制及治疗效果的既往和当前知识进行分类和总结，以促进这种天然产物的临床应用。
本文综述了Rh2的抗癌功效及机制，包括诱导细胞周期停滞和程序性细胞死亡、抑制转移、减轻耐药性以及调节免疫系统。最后，本文讨论了Rh2的研究及应用前景。
