Postdoctoral research workstation, Jilin Cancer Hospital, Changchun, China; Department of 1st Gynecologic Oncology Surgery, Jilin Cancer Hospital, Changchun, China.
Department of Medical Thoracic Oncology, Jilin Cancer Hospital, Changchun, China.
Biomed Pharmacother. 2022 Dec;156:113912. doi: 10.1016/j.biopha.2022.113912. Epub 2022 Oct 23.
Ginsenoside Rh2 (Rh2), the major bio-active ginsenoside that originated from the root of Panax ginseng, has become a "hot topic" for playing multifunctional roles in both tumor treatment and tumor microenvironment (TME) immunomodulation. Up to now, emerging experimental research about Rh2 in tumor therapy and immuno-regulation has been published, however, the specific reviews focused on its role in the TME were limited. Hence, in this article, we briefly summarized existing evidence supporting the anticancer effects and potential mechanisms of Rh2 according to the tumor type, including anti-proliferation, anti-invasion, and metastasis, induction of cell cycle arrest, anti-angiogenesis, promotion of reactive oxygen species and differentiation. Meanwhile, we shed light on the role of Rh2 in TME, with an emphasis on regulating tumor immunogenicity, immune cells, cytokines, and physicochemical properties of TME. Finally, the current research limitation and prospects of Rh2 were discussed.
人参皂苷 Rh2（Rh2）是源于人参根的主要生物活性人参皂苷，已成为在肿瘤治疗和肿瘤微环境（TME）免疫调节中发挥多功能作用的“热门话题”。到目前为止，有关 Rh2 在肿瘤治疗和免疫调节中的新兴实验研究已经发表，但是，针对其在 TME 中作用的具体综述有限。因此，在本文中，我们根据肿瘤类型简要总结了现有证据支持 Rh2 的抗癌作用及其潜在机制，包括抗增殖、抗侵袭和转移、诱导细胞周期停滞、抗血管生成、促进活性氧和分化。同时，我们探讨了 Rh2 在 TME 中的作用，重点是调节肿瘤免疫原性、免疫细胞、细胞因子和 TME 的物理化学性质。最后，讨论了 Rh2 当前的研究局限性和前景。
