Li Jin, Bao Junqiang, Gao Chao, Wei Zibin, Tan Liguo, Liu Ping, Wang Zhiwei, Tian Shujuan
Department of Neurosurgery, The Affiliated Hospital of the Nco School, The Army Medical University, Shijiazhuang, 050041, Hebei, People's Republic of China.
Department of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, 050030, Hebei, People's Republic of China.
Int J Gen Med. 2021 Mar 2;14:733-739. doi: 10.2147/IJGM.S292171. eCollection 2021.
Previous studies have reported that patients with stroke have a high incidence of cognitive decline. The aim was to elucidate the association between serum E-selectin levels and cognitive function in stroke patients.
Serum levels of E-selectin were measured in 322 patients with stroke at baseline. Cox proportional hazard analysis was used to evaluate the predictive value of serum E-selectin for predicting cognitive decline (end point) in patients with stroke.
Multivariate linear regression analysis revealed that serum E-selectin levels were independently associated with MOCA score after adjusting for age, gender, BMI, current smoker, current drinker, admission systolic and diastolic BP, CVD history and laboratory measurements in patients with stroke at baseline (Sβ= -0.156; 95% CI, - 0.170- - 0.074; 0.001). The multivariate Cox proportional hazard analysis revealed that serum E-selectin (HR=2.481, 95% CI 1.533-4.327, -trend <0.001) was an independent prognostic factor for cognitive decline in these patients with stroke during the follow-up period.
Our results showed that increased serum E-selectin levels were significantly and independently associated with cognitive decline and had independent predictive value for cognitive decline in patients with stroke. Serum E-selectin might enable early recognition of cognitive decline among stroke patients.
既往研究报道，中风患者认知功能下降的发生率较高。目的是阐明中风患者血清E选择素水平与认知功能之间的关联。
在322例中风患者基线时测量血清E选择素水平。采用Cox比例风险分析评估血清E选择素对中风患者认知功能下降（终点）的预测价值。
多因素线性回归分析显示，在对基线时中风患者的年龄、性别、体重指数、当前吸烟者、当前饮酒者、入院时收缩压和舒张压、心血管疾病史及实验室检查结果进行校正后，血清E选择素水平与蒙特利尔认知评估量表（MOCA）评分独立相关（标准化β=-0.156；95%可信区间，-0.170～-0.074；P=0.001）。多因素Cox比例风险分析显示，血清E选择素（风险比=2.481，95%可信区间1.533～4.327，P趋势<0.001）是这些中风患者随访期间认知功能下降的独立预后因素。
我们的结果表明，血清E选择素水平升高与认知功能下降显著且独立相关，对中风患者的认知功能下降具有独立预测价值。血清E选择素可能有助于早期识别中风患者的认知功能下降。
