Lemu Lidiya Gutema, Woldu Biruktawit Fekade, Teke Natnael Eshetu, Bogale Nardos Delelegn, Wondimenew Ermias Ayalew
Department of Midwifery, College of Health Science, Mizan Tepi University, Mizan-Aman, Ethiopia.
Department of Midwifery, College of Medicine and Health Science, Wachemo University, Hossana, Ethiopia.
Int J Womens Health. 2021 Mar 3;13:297-303. doi: 10.2147/IJWH.S295137. eCollection 2021.
Despite being one of the few cancers that can be prevented with simple testing, cervical cancer is the fourth most common cancer in women. HIV-positive women showed a median three-fold higher incidence of cervical lesions.
This study aims to assess the prevalence and factors associated with precancerous cervical lesions among HIV-infected women attending care and treatment clinic in selected hospitals of Southwestern Ethiopia.
Institution-based cross-sectional study was conducted from February 1 to July 30, 2018. A systematic random sampling technique was employed to select 454 HIV-infected women. Pretested interviewer-administered questionnaire and medical record review were used for data collection. Visual inspection with Acetic acid was done for participants to detect precancerous cervical lesions. Data were analyzed by SPSS version 20. Binary and multiple logistic regression analyses were done. The presence and strength of association were determined using AOR with its 95% CI. Variables with a P value of less than 0.05 were considered as statistically significant.
The prevalence of precancerous cervical lesion was 18.7% [95% CI; (15.1-22.4%)]. Currently, not being on highly active antiretroviral treatment [AOR= 2.31, 95% CI: 1.23-4.39], age (20-29 years) [AOR= 0.185, 95% CI: 0.036,0.939], has no history of sexually transmitted infection [AOR=0.026, 95% CI: 0.006-0.116], has no history of genital wart [AOR= 0.261, 95% CI: 0.073-0.934] and having one lifetime sexual partner [AOR=0.133, 95% CI: 0.024-0.726] were found to be significantly associated with precancerous cervical lesion.
The prevalence of Precancerous Cervical lesion was found to be high in this study. Expansion of screening services and undertaking preventive measures against sexually transmitted infection need to be emphasized.
尽管宫颈癌是少数几种可通过简单检测预防的癌症之一，但它仍是女性中第四大常见癌症。艾滋病毒呈阳性的女性患宫颈病变的发病率中位数高出三倍。
本研究旨在评估埃塞俄比亚西南部选定医院接受护理和治疗诊所的艾滋病毒感染女性中宫颈癌前病变的患病率及相关因素。
2018年2月1日至7月30日进行了基于机构的横断面研究。采用系统随机抽样技术选取454名艾滋病毒感染女性。通过预先测试的访谈式问卷和病历审查进行数据收集。对参与者进行醋酸目视检查以检测宫颈癌前病变。数据采用SPSS 20版进行分析。进行二元和多元逻辑回归分析。使用调整后的比值比（AOR）及其95%置信区间确定关联的存在和强度。P值小于0.05的变量被视为具有统计学意义。
宫颈癌前病变的患病率为18.7% [95%置信区间；（15.1 - 22.4%）]。目前，未接受高效抗逆转录病毒治疗 [AOR = 2.31，95%置信区间：1.23 - 4.39]、年龄（20 - 29岁）[AOR = 0.185，95%置信区间：0.036，0.939]、无性传播感染史 [AOR = 0.026，95%置信区间：0.006 - 0.116]、无尖锐湿疣病史 [AOR = 0.261，95%置信区间：0.073 - 0.934] 以及一生只有一个性伴侣 [AOR = 0.133，95%置信区间：0.024 - 0.726] 被发现与宫颈癌前病变显著相关。
本研究发现宫颈癌前病变的患病率很高。需要强调扩大筛查服务以及采取预防性传播感染的措施。
