Merera Desalegn, Jima Gebi Husein
Oromia Regional Health Bureau, Adama, Ethiopia.
Department of Public Health, College of Health Science, Arsi University, Asella, Ethiopia.
Cancer Manag Res. 2021 Mar 3;13:2181-2189. doi: 10.2147/CMAR.S288398. eCollection 2021.
Cervical cancer is the third most common form of cancer among women worldwide. Yet it is one of the few cancers that can be detected and prevented at precancerous stage. Even though different studies were conducted in different areas in Ethiopia, the risk factors for cervical precancerous lesions in the Ethiopian setting are not well identified.
To determine prevalence of precancerous cervical lesion and associated factors among women of reproductive age group attending screening center at Adama Hospital and Medical College.
A cross-sectional study was carried out from June 11 to July 11, 2019. Data was collected through interview aided questionnaires and visual inspection with acetic acid applied for screening and treatment. A random sample of 293 were included in the study. Data was entered into Epi Info version 7, and analyzed by SPSS version 21. Descriptive analysis was conducted to describe the study population and a logistic regression analysis was applied to assess the association of independent variables with the outcome variable. The level of significance of association was determined at p- value<0.05.
Out of the total 293 screened women, 15.7% (95% CI: 11.3%-20.1%) were found to be positive for precancerous cervical lesion. After controlling for the effect of other confounding factors, four variables, absence of menses (adjusted odds ratio (AOR) = 0.18, 95% CI (0.04, 0.87)), history of pelvic infection [AOR = 2.82; 95% CI (1.21, 6.59)], history of STI [AOR = 2.65; 95% CI (1.26, 5.56)] and having a partner who had another partner [AOR = 2.41; 95% CI (1.08, 5.38)] were found to be significantly associated with precancerous cervical cancer at cut-off point p-value less than 0.05.
Menstrual history, history of pelvic infection, history of STI, and had a partner who had another partner were found to be significantly associated with precancerous cervical lesion.
宫颈癌是全球女性中第三大常见癌症形式。然而，它是少数几种能够在癌前阶段被检测和预防的癌症之一。尽管在埃塞俄比亚的不同地区开展了不同的研究，但埃塞俄比亚环境下宫颈癌前病变的危险因素尚未得到很好的识别。
确定在阿达马医院和医学院筛查中心就诊的育龄期女性中癌前宫颈病变的患病率及相关因素。
于2019年6月11日至7月11日进行了一项横断面研究。通过访谈辅助问卷以及应用醋酸进行筛查和治疗的视觉检查来收集数据。研究纳入了293名随机样本。数据录入Epi Info 7版本，并使用SPSS 21版本进行分析。进行描述性分析以描述研究人群，并应用逻辑回归分析来评估自变量与结果变量之间的关联。关联的显著性水平在p值<0.05时确定。
在总共293名接受筛查的女性中，发现15.7%（95%置信区间：11.3%-20.1%）的癌前宫颈病变呈阳性。在控制了其他混杂因素的影响后，发现四个变量，即闭经（调整后的优势比（AOR）=0.18，95%置信区间（0.04，0.87））、盆腔感染史[AOR = 2.82；95%置信区间（1.21，6.59）]、性传播感染史[AOR = 2.65；95%置信区间（1.26，5.56）]以及伴侣有其他伴侣[AOR = 2.41；95%置信区间（1.08，5.38）]在截断点p值小于0.05时与癌前宫颈癌显著相关。
月经史、盆腔感染史、性传播感染史以及伴侣有其他伴侣被发现与癌前宫颈病变显著相关。
