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重症监护病房中右美托咪定诱发的多尿

Dexmedetomidine Induced Polyuria in the Intensive Care Unit.

作者信息

Uddin Mohammed M, Sebastian Joseph, Usama Muhammad, Raziq Fazal I, Saydain Ghulam, Rossi Noreen F

机构信息

Internal Medicine, Wayne State University/Detroit Medical Center, 4201 St Antoine, Detroit, MI 48201, USA.

Internal Medicine, Michigan State University/Sparrow Hospital, 1215 E Michigan Ave, Lansing, MI 48912, USA.

出版信息

Case Rep Crit Care. 2021 Feb 20;2021:8850116. doi: 10.1155/2021/8850116. eCollection 2021.

DOI:10.1155/2021/8850116
PMID:33688441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7920733/
Abstract

Dexmedetomidine is an 2-adrenergic used as an adjunct therapy for sedation in the intensive care unit. While it is known to cause polyuria exclusively in perioperative conditions, not many cases are known in the intensive care unit, thus making the diagnosis challenging. We present the case of a 61-year-old male who had developed polyuria secondary to central diabetes insipidus after receiving dexmedetomidine intravenous infusion in the medical ICU. Increased awareness of this uncommon side effect of dexmedetomidine will help clinicians recognize and address it early.

摘要

右美托咪定是一种α2肾上腺素能药物，用作重症监护病房镇静的辅助治疗药物。虽然已知它仅在围手术期会导致多尿，但在重症监护病房中这种情况并不多见，因此诊断具有挑战性。我们报告一例61岁男性病例，该患者在医学重症监护病房接受右美托咪定静脉输注后，因中枢性尿崩症继发多尿。提高对右美托咪定这种罕见副作用的认识将有助于临床医生早期识别并处理它。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/690c/7920733/4bc418d6e54c/CRICC2021-8850116.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/690c/7920733/4bc418d6e54c/CRICC2021-8850116.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/690c/7920733/4bc418d6e54c/CRICC2021-8850116.001.jpg

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本文引用的文献

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Intraoperative dexmedetomidine-induced polyuria from a loading dose: a case report.术中负荷剂量右美托咪定引起的多尿：一例报告。
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A Synaptically Connected Hypothalamic Magnocellular Vasopressin-Locus Coeruleus Neuronal Circuit and Its Plasticity in Response to Emotional and Physiological Stress.一个通过突触连接的下丘脑大细胞血管加压素-蓝斑神经元回路及其对情绪和生理应激反应的可塑性。
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The Effect of Propofol and Dexmedetomidine Sedation on Norepinephrine Requirements in Septic Shock Patients: A Crossover Trial.
异丙酚和右美托咪定镇静对脓毒性休克患者去甲肾上腺素需求的影响：一项交叉试验。
Crit Care Med. 2019 Feb;47(2):e89-e95. doi: 10.1097/CCM.0000000000003520.
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Intraoperative Dexmedetomidine-Induced Polyuric Syndrome.术中右美托咪定诱发的多尿综合征
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