Rodovalho G V, Franci C R, Morris M, Anselmo-Franci J A
Departamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
Neurochem Res. 2006 Feb;31(2):259-66. doi: 10.1007/s11064-005-9015-5. Epub 2006 Mar 10.
The role of the noradrenergic nucleus Locus Coeruleus (LC) on hemorrhage-induced vasopressin (AVP) and oxytocin (OT) secretion was examined. Rats with LC lesion were submitted to three 1-min hemorrhage sessions at 5-min intervals; 15% of the total blood volume was withdrawn in each session. OT and AVP were measured in plasma, paraventricular (PVN) and supraoptic (SON) nuclei and in posterior pituitary (PP). LC Lesion did not affect basal plasma AVP or OT levels, but partly blocked the increase in plasma AVP and OT induced by hemorrhage. Hemorrhage produced decreases in content of AVP and OT in the PVN and SON and increased levels in the PP. These responses were attenuated in the lesioned group, but only in the PVN and PP. Data suggest a stimulatory role of the inputs from LC to PVN neurons on hemorrhage-induced OT and AVP secretion and that, this pathway is critical in the hypo-volemic neuroendocrine reflex.
研究了去甲肾上腺素能蓝斑核（LC）在出血诱导的血管加压素（AVP）和催产素（OT）分泌中的作用。对LC损伤的大鼠每隔5分钟进行3次1分钟的出血实验；每次实验抽取总血量的15%。检测血浆、室旁核（PVN）、视上核（SON）以及垂体后叶（PP）中的OT和AVP。LC损伤不影响基础血浆AVP或OT水平，但部分阻断了出血诱导的血浆AVP和OT的升高。出血导致PVN和SON中AVP和OT含量降低，PP中水平升高。这些反应在损伤组中减弱，但仅在PVN和PP中。数据表明，LC向PVN神经元的输入对出血诱导的OT和AVP分泌具有刺激作用，并且该通路在低血容量神经内分泌反射中至关重要。
