• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

泛肾细胞癌脂肪酸代谢通路的比较：生物信息学证据。

Comparison of the Fatty Acid Metabolism Pathway in Pan-Renal Cell Carcinoma: Evidence from Bioinformatics.

机构信息

Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.

Department of Urology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

出版信息

Anal Cell Pathol (Amst). 2021 Feb 22;2021:8842105. doi: 10.1155/2021/8842105. eCollection 2021.

DOI:10.1155/2021/8842105
PMID:33688464
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7925032/
Abstract

This study analyzed and compared the potential role of fatty acid metabolism pathways in three subtypes of renal cell carcinoma. Biological pathways that were abnormally up- and downregulated were identified through gene set variation analysis in the subtypes. Abnormal downregulation of the fatty acid metabolism pathway occurred in all three renal cell carcinoma subtypes. Alteration of the fatty acid metabolism pathway was vital in the development of pan-renal cell carcinoma. Bioinformatics methods were used to obtain a panoramic view of copy number variation, single-nucleotide variation, mRNA expression, and the survival landscape of fatty acid metabolism pathway-related genes in pan-renal cell carcinoma. Most importantly, we used genes related to the fatty acid metabolism pathway to establish a prognostic-related risk model in the three subtypes of renal cell carcinoma. The data will be valuable for future clinical treatment and scientific research.

摘要

本研究分析并比较了脂肪酸代谢途径在三种肾细胞癌亚型中的潜在作用。通过对各亚型的基因集变异分析，确定了异常上调和下调的生物学途径。在所有三种肾细胞癌亚型中，脂肪酸代谢途径均出现异常下调。脂肪酸代谢途径的改变对泛肾细胞癌的发生至关重要。生物信息学方法用于获得泛肾细胞癌中脂肪酸代谢途径相关基因的拷贝数变异、单核苷酸变异、mRNA 表达和生存景观的全景图。最重要的是，我们使用与脂肪酸代谢途径相关的基因在三种肾细胞癌亚型中建立了一个预后相关的风险模型。这些数据将对未来的临床治疗和科学研究具有重要价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f82d/7925032/a2f990197f5d/ACP2021-8842105.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f82d/7925032/b3297a568e29/ACP2021-8842105.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f82d/7925032/c5effe89611c/ACP2021-8842105.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f82d/7925032/5afd313e30c3/ACP2021-8842105.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f82d/7925032/ce48c175b527/ACP2021-8842105.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f82d/7925032/322c2974d468/ACP2021-8842105.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f82d/7925032/6863c144f853/ACP2021-8842105.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f82d/7925032/a2f990197f5d/ACP2021-8842105.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f82d/7925032/b3297a568e29/ACP2021-8842105.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f82d/7925032/c5effe89611c/ACP2021-8842105.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f82d/7925032/5afd313e30c3/ACP2021-8842105.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f82d/7925032/ce48c175b527/ACP2021-8842105.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f82d/7925032/322c2974d468/ACP2021-8842105.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f82d/7925032/6863c144f853/ACP2021-8842105.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f82d/7925032/a2f990197f5d/ACP2021-8842105.007.jpg

相似文献

1
Comparison of the Fatty Acid Metabolism Pathway in Pan-Renal Cell Carcinoma: Evidence from Bioinformatics.泛肾细胞癌脂肪酸代谢通路的比较：生物信息学证据。
Anal Cell Pathol (Amst). 2021 Feb 22;2021:8842105. doi: 10.1155/2021/8842105. eCollection 2021.
2
A cluster of metabolism-related genes predict prognosis and progression of clear cell renal cell carcinoma.一组与代谢相关的基因可预测透明细胞肾细胞癌的预后和进展。
Sci Rep. 2020 Jul 31;10(1):12949. doi: 10.1038/s41598-020-67760-6.
3
Expression of BAG1 is associated with prognosis in kidney renal clear cell carcinoma based on bioinformatics.基于生物信息学，BAG1 的表达与肾透明细胞癌的预后相关。
BMC Cancer. 2021 Feb 13;21(1):160. doi: 10.1186/s12885-021-07874-w.
4
Low level of PDZ domain containing 1 (PDZK1) predicts poor clinical outcome in patients with clear cell renal cell carcinoma.含PDZ结构域蛋白1（PDZK1）水平低预示着透明细胞肾细胞癌患者的临床预后较差。
EBioMedicine. 2017 Feb;15:62-72. doi: 10.1016/j.ebiom.2016.12.003. Epub 2016 Dec 9.
5
Diagnostic biomarkers for renal cell carcinoma: selection using novel bioinformatics systems for microarray data analysis.肾细胞癌的诊断生物标志物：使用新型生物信息学系统进行微阵列数据分析以进行选择。
Hum Pathol. 2009 Dec;40(12):1671-8. doi: 10.1016/j.humpath.2009.05.006. Epub 2009 Aug 19.
6
Identification and validation of novel prognostic markers in Renal Cell Carcinoma.肾细胞癌中新型预后标志物的鉴定与验证
Dan Med J. 2017 Oct;64(10).
7
The panoramic picture of pepsinogen gene family with pan-cancer.胃蛋白酶原基因家族的全景图与泛癌。
Cancer Med. 2020 Dec;9(23):9064-9080. doi: 10.1002/cam4.3489. Epub 2020 Oct 17.
8
Identification of the key genes and pathways involved in the tumorigenesis and prognosis of kidney renal clear cell carcinoma.鉴定参与肾透明细胞癌发生和预后的关键基因和通路。
Sci Rep. 2020 Mar 6;10(1):4271. doi: 10.1038/s41598-020-61162-4.
9
Overexpression of FABP7 promotes cell growth and predicts poor prognosis of clear cell renal cell carcinoma.脂肪酸结合蛋白7（FABP7）的过表达促进细胞生长并预示着透明细胞肾细胞癌的预后不良。
Urol Oncol. 2015 Mar;33(3):113.e9-17. doi: 10.1016/j.urolonc.2014.08.001. Epub 2014 Sep 2.
10
Brain-type and liver-type fatty acid-binding proteins: new tumor markers for renal cancer?脑型和肝型脂肪酸结合蛋白：肾癌的新型肿瘤标志物？
BMC Cancer. 2009 Jul 21;9:248. doi: 10.1186/1471-2407-9-248.

引用本文的文献

1
Study on HOXBs of Clear Cell Renal Cell Carcinoma and Detection of New Molecular Target.透明细胞肾细胞癌中HOXB基因的研究及新分子靶点的检测
J Oncol. 2021 Jul 8;2021:5541423. doi: 10.1155/2021/5541423. eCollection 2021.

本文引用的文献

1
Glycolysis-Related Genes Serve as Potential Prognostic Biomarkers in Clear Cell Renal Cell Carcinoma.糖酵解相关基因可作为透明细胞肾细胞癌的潜在预后生物标志物。
Oxid Med Cell Longev. 2021 Jan 23;2021:6699808. doi: 10.1155/2021/6699808. eCollection 2021.
2
A New Prognostic Risk Model Based on PPAR Pathway-Related Genes in Kidney Renal Clear Cell Carcinoma.一种基于PPAR通路相关基因的肾透明细胞癌新预后风险模型
PPAR Res. 2020 Sep 22;2020:6937475. doi: 10.1155/2020/6937475. eCollection 2020.
3
Screening and Identification of Key Biomarkers for Bladder Cancer: A Study Based on TCGA and GEO Data.
基于 TCGA 和 GEO 数据的膀胱癌关键生物标志物的筛选和鉴定：一项研究。
Biomed Res Int. 2020 Jan 23;2020:8283401. doi: 10.1155/2020/8283401. eCollection 2020.
4
Reprogramming of fatty acid metabolism in cancer.癌症中脂肪酸代谢的重编程。
Br J Cancer. 2020 Jan;122(1):4-22. doi: 10.1038/s41416-019-0650-z. Epub 2019 Dec 10.
5
Study of FABP's interactome and detecting new molecular targets in clear cell renal cell carcinoma.研究 FABP 的相互作用组并检测透明细胞肾细胞癌中的新分子靶点。
J Cell Physiol. 2020 Apr;235(4):3776-3789. doi: 10.1002/jcp.29272. Epub 2019 Oct 10.
6
CPT1A Supports Castration-Resistant Prostate Cancer in Androgen-Deprived Conditions.CPT1A 在去势抵抗性前列腺癌的雄激素剥夺条件下发挥作用。
Cells. 2019 Sep 20;8(10):1115. doi: 10.3390/cells8101115.
7
FABP5 is correlated with poor prognosis and promotes tumour cell growth and metastasis in clear cell renal cell carcinoma.FABP5 与不良预后相关，并促进透明细胞肾细胞癌中的肿瘤细胞生长和转移。
Eur J Pharmacol. 2019 Nov 5;862:172637. doi: 10.1016/j.ejphar.2019.172637. Epub 2019 Sep 3.
8
Targeting the transcription factor receptor LXR to treat clear cell renal cell carcinoma: agonist or inverse agonist?靶向转录因子受体 LXR 治疗透明细胞肾细胞癌：激动剂还是反向激动剂？
Cell Death Dis. 2019 May 28;10(6):416. doi: 10.1038/s41419-019-1654-6.
9
Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity.证据表明，另一种脂肪酸去饱和途径会增加癌症的可塑性。
Nature. 2019 Feb;566(7744):403-406. doi: 10.1038/s41586-019-0904-1. Epub 2019 Feb 6.
10
STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets.STRING v11：具有增强覆盖范围的蛋白质-蛋白质相互作用网络，支持在全基因组实验数据集的功能发现。
Nucleic Acids Res. 2019 Jan 8;47(D1):D607-D613. doi: 10.1093/nar/gky1131.