釉基质衍生物与龈下再治疗：一项初步研究。

Enamel matrix derivative and subgingival reinstrumentation: a pilot study.

出版信息

Quintessence Int. 2021 May 7;52(6):506-513. doi: 10.3290/j.qi.b1044079.

DOI:10.3290/j.qi.b1044079

Abstract

OBJECTIVES

To verify the effect of adjunctive enamel matrix derivative (EMD) in subgingival reinstrumentation during supportive periodontal therapy.

METHOD AND MATERIALS

Using a split-mouth design, residual periodontal pockets with probing depth (PD) of 5 to 8 mm in 13 patients were treated by subgingival reinstrumentation with (test teeth) and without (control teeth) EMD. At baseline and after 6 and 12 months the clinical variables PD, clinical attachment level (CAL), and bleeding on probing (BOP) were recorded. At the same appointments gingival crevicular fluid (GCF) was collected to analyze for interleukin (IL)-1β, matrix metalloproteinase (MMP)-8, IL-10, and transforming growth factor (TGF)-β.

RESULTS

Statistically significant improvements in PD, CAL, and BOP occurred in both groups. The reduction of PD was significantly higher in the test group than in the control group after 12 months (P = .005). The change of IL-1β within 12 months was significantly different between both groups (P = .019). No other significant differences were detected between both groups.

CONCLUSION

The study suggests that subgingival reinstrumentation with adjunctive EMD could additionally reduce probing pocket depth and the need for periodontal surgery. (Quintessence Int 2021;52:506-513; doi: 10.3290/j.qi.b1044079).

摘要

目的

验证在牙周支持治疗期间，辅助性釉基质衍生物（EMD）在龈下再治疗中的作用。

方法和材料

采用分口设计，13 名患者的牙周袋残留有 5 至 8 毫米的探诊深度（PD），用龈下再治疗方法进行治疗，并用（试验牙）和不用（对照牙）EMD。在基线、6 个月和 12 个月时记录临床变量 PD、临床附着水平（CAL）和探诊出血（BOP）。在相同的预约中收集龈沟液（GCF），以分析白细胞介素（IL）-1β、基质金属蛋白酶（MMP）-8、IL-10 和转化生长因子（TGF）-β。