DDX41 缺失 R 环激活 cGAS 驱动炎性 HSPC 产生。
Ddx41 loss R-loops in cGAS to fuel inflammatory HSPC production.
机构信息
Stem Cell Program, Department of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.
Stem Cell Program, Department of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.
出版信息
Dev Cell. 2021 Mar 8;56(5):571-572. doi: 10.1016/j.devcel.2021.02.014.
In this issue of Developmental Cell, Weinreb et al. reveal that loss of the DEAD-box helicase Ddx41 unexpectedly triggers an R-loop-mediated sterile inflammatory cascade which drives HSPC production during embryonic development. Human studies suggest mechanistic conservation for inflammation in DDX41-associated hematologic disease, uncovering a potential route for future therapeutic intervention.
本期《发育细胞》中，Weinreb 等人揭示了 DEAD -box 解旋酶 Ddx41 的缺失出人意料地引发了 R 环介导的无菌性炎症级联反应，从而在胚胎发育过程中驱动 HSPC 的产生。人类研究表明，DDX41 相关血液疾病中的炎症存在机制保守性，这揭示了未来治疗干预的潜在途径。
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