Translational Hematology and Oncology Research Department, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH.
Department of Biomedicine and Prevention, Tor Vergata University of Rome, Rome, Italy.
Blood. 2021 Jul 1;137(26):3685-3689. doi: 10.1182/blood.2021010811.
Cytoplasmic vacuoles in precursors can be seen in a number of clinical settings, including copper deficiency, zinc toxicity, alcohol abuse, antibiotic treatment, myelodysplasia, and VEXAS syndrome. Gurnari et al asked how common VEXAS syndrome is in patients whose bone marrow aspirates show this distinctive feature, finding 2 diagnoses of VEXAS among 24 cases with vacuoles.
在多种临床情况下，包括铜缺乏、锌中毒、酒精滥用、抗生素治疗、骨髓增生异常和 VEXAS 综合征，可以看到前体细胞中的细胞质空泡。Gurnari 等人想知道骨髓抽吸物显示这种特征的患者中 VEXAS 综合征的常见程度，在 24 例有空泡的病例中发现 2 例 VEXAS 诊断。
