学习与中风康复：生物学基质的并行性。
Learning and Stroke Recovery: Parallelism of Biological Substrates.
机构信息
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California.
出版信息
Semin Neurol. 2021 Apr;41(2):147-156. doi: 10.1055/s-0041-1725136. Epub 2021 Mar 9.
Abstract
Stroke is a debilitating disease. Current effective therapies for stroke recovery are limited to neurorehabilitation. Most stroke recovery occurs in a limited and early time window. Many of the mechanisms of spontaneous recovery after stroke parallel mechanisms of normal learning and memory. While various efforts are in place to identify potential drug targets, an emerging approach is to understand biological correlates between learning and stroke recovery. This review assesses parallels between biological changes at the molecular, structural, and functional levels during learning and recovery after stroke, with a focus on drug and cellular targets for therapeutics.
摘要
中风是一种使人虚弱的疾病。目前治疗中风恢复的有效方法仅限于神经康复。中风后的大部分恢复发生在有限的早期时间窗内。中风后自发恢复的许多机制与正常学习和记忆的机制平行。虽然正在努力确定潜在的药物靶点，但一种新兴的方法是了解学习和中风恢复之间的生物学相关性。本综述评估了学习过程中分子、结构和功能水平上的生物学变化与中风后恢复之间的相似之处，重点是治疗的药物和细胞靶点。
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