Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, Wound Healing and Regenerative Medicine Research Program, University of Miami Miller School of Medicine, Miami, FL, USA.
Exp Dermatol. 2021 Aug;30(8):1073-1089. doi: 10.1111/exd.14325. Epub 2021 Apr 1.
Stringent spatiotemporal regulation of the wound healing process involving multiple cell types is associated with epigenetic mechanisms of gene regulation, such as DNA methylation, histone modification and chromatin remodelling, as well as non-coding RNAs. Here, we discuss the epigenetic changes that occur during wound healing and the rapidly expanding understanding of how these mechanisms affect healing resolution in both acute and chronic wound milieu. We provide a focussed overview of current research into epigenetic regulators that contribute to wound healing by specific cell type. We highlight the role of epigenetic regulators in the molecular pathophysiology of chronic wound conditions. The understanding of how epigenetic regulators can affect cellular functions during normal and impaired wound healing could lead to novel therapeutic approaches, and we outline questions that can provide guidance for future research on epigenetic-based interventions to promote healing. Dissecting the dynamic interplay between cellular subtypes involved in wound healing and epigenetic parameters during barrier repair will deepen our understanding of how to improve healing outcomes in patients affected by chronic non-healing wounds.
严格的时空调节涉及多种细胞类型的伤口愈合过程与基因调控的表观遗传机制有关，如 DNA 甲基化、组蛋白修饰和染色质重塑，以及非编码 RNA。在这里，我们讨论了在伤口愈合过程中发生的表观遗传变化，以及这些机制如何影响急性和慢性伤口环境中愈合的迅速扩展的理解。我们提供了一个关于特定细胞类型对伤口愈合有贡献的表观遗传调节剂的最新研究的重点概述。我们强调了表观遗传调节剂在慢性伤口状况的分子病理生理学中的作用。了解表观遗传调节剂如何在正常和受损的伤口愈合过程中影响细胞功能，可能会导致新的治疗方法，我们概述了可以为基于表观遗传的干预促进愈合的未来研究提供指导的问题。剖析参与伤口愈合的细胞亚型与屏障修复过程中的表观遗传参数之间的动态相互作用，将加深我们对如何改善受慢性非愈合性伤口影响的患者的愈合结果的理解。
