Kanoujia Jovita, Raina Neha, Kishore Ankita, Kaurav Monika, Tuli Hardeep Singh, Kumar Akhilesh, Gupta Madhu
Amity Institute of Pharmacy, Amity University Madhya Pradesh (AUMP), Gwalior, 474005, Madhya Pradesh, India.
Department of Pharmaceutics, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, Pushp Vihar, New Delhi, 110017, India.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Jun;398(6):6617-6641. doi: 10.1007/s00210-024-03761-w. Epub 2025 Jan 31.
Chronic wounds significantly contribute to disability and affect the mortality rate in diabetic patients. In addition, pressure ulcers, diabetic foot ulcers, arterial ulcers, and venous ulcers pose a significant health burden due to their associated morbidity and death. The complex healing process, environmental factors, and genetic factors have been identified as the rate-limiting stages of chronic wound healing. Changes in temperature, moisture content, mechanical strain, and genetics can result in slow wound healing, increased susceptibility to bacterial infections, and poor matrix remodelling. These obstacles can be addressed with natural biomaterials exhibiting antimicrobial, collagen synthesis, and granulation tissue formation properties. Recently, silk proteins have gained significant attention as a natural biomaterial owing to good biocompatibility, biodegradability, reduced immunogenicity, ease of sterilization, and promote the wound healing process. The silk components such as sericin and fibroin in combination with nano(platforms) effectively promote wound repair. This review emphasises the potential of sericin and fibroin when combined with nano(platforms) like nanoparticles, nanofibers, and nanoparticles-embedded films, membranes, gels, and nanofibers.
慢性伤口是导致糖尿病患者残疾的重要因素，并影响其死亡率。此外，压疮、糖尿病足溃疡、动脉溃疡和静脉溃疡因其相关的发病率和死亡率，构成了重大的健康负担。复杂的愈合过程、环境因素和遗传因素已被确定为慢性伤口愈合的限速阶段。温度、水分含量、机械应变和基因的变化可导致伤口愈合缓慢、细菌感染易感性增加以及基质重塑不良。这些障碍可以通过具有抗菌、胶原蛋白合成和肉芽组织形成特性的天然生物材料来解决。近年来，丝蛋白作为一种天然生物材料因其良好的生物相容性、生物降解性、降低的免疫原性、易于灭菌以及促进伤口愈合过程而备受关注。丝胶蛋白和丝素蛋白等丝成分与纳米（平台）相结合可有效促进伤口修复。本综述强调了丝胶蛋白和丝素蛋白与纳米颗粒、纳米纤维以及嵌入纳米颗粒的薄膜、膜、凝胶和纳米纤维等纳米（平台）结合时的潜力。
