痤疮患者的维生素D状况及维生素D补充剂的疗效：一项系统评价和荟萃分析。
Vitamin D status and efficacy of vitamin D supplementation in acne patients: A systematic review and meta-analysis.
作者信息
Wang Meng, Zhou Yuan, Yan Yan
机构信息
Department of Dermatology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
出版信息
J Cosmet Dermatol. 2021 Dec;20(12):3802-3807. doi: 10.1111/jocd.14057. Epub 2021 Apr 15.
BACKGROUND
Acne vulgaris, a chronic inflammatory dermatosis, affects approximately 85% of adolescents and young adults.The level of vitamin D in acne patients and the effect on acne patients of a vitamin D supplementation have previously been documented; however, it remains to be disputed whether vitamin D deficiency is normal in acne patients.
AIMS
This paper explores the relationship between vitamin D and acne levels and the advantageous implications of vitamin D supplements on acne.
METHODS
From every database start date until December 2020, we checked the PubMed, EMBASE, MEDLINE and the Cochrane libraries. Case-controls or randomized controlled trial reporting on the serum 25(OH)D level and the efficacy of vitamin D supplement to acne patients were included.
RESULTS
The serum 25(OH)D levels in acne patients is lower (standardized mean difference = -7.66 ng/ml; 95% confidence interval (CI) = -10.92 to -4.40). Articles also revealed the prospect of a therapeutic breakthrough through the supplementing of vitamin D for acne patients.
CONCLUSION
Our research offers a new guide in the field of acne prevention and health care.
背景
寻常痤疮是一种慢性炎症性皮肤病，影响约85%的青少年和年轻人。此前已有文献记载痤疮患者的维生素D水平以及补充维生素D对痤疮患者的影响；然而，痤疮患者维生素D缺乏是否常见仍存在争议。
目的
本文探讨维生素D与痤疮水平之间的关系以及维生素D补充剂对痤疮的有益影响。
方法
从每个数据库起始日期至2020年12月，我们检索了PubMed、EMBASE、MEDLINE和Cochrane图书馆。纳入报告血清25(OH)D水平以及维生素D补充剂对痤疮患者疗效的病例对照或随机对照试验。
结果
痤疮患者的血清25(OH)D水平较低（标准化平均差=-7.66 ng/ml；95%置信区间(CI)=-10.92至-4.40）。文章还揭示了通过为痤疮患者补充维生素D实现治疗突破的前景。
结论
我们的研究为痤疮预防和医疗保健领域提供了新的指导。
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