星形胶质细胞的完全 OSM 赠品可减轻炎症。
A totally OSM gift to astrocytes relieves inflammation.
机构信息
Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.
出版信息
Immunity. 2021 Mar 9;54(3):401-403. doi: 10.1016/j.immuni.2021.02.011.
PMID:33691129
Abstract
Dectin-1 is known for promoting anti-fungal responses through the signaling molecule Card9. In this issue of Immunity, Deerhake et al. now report that during autoimmune neuroinflammation, Dectin-1 can promote a neuroprotective feed-forward pathway through Card9-independent upregulation of Oncostatin M.
摘要
Dectin-1 通过信号分子 Card9 促进抗真菌反应。在本期《Immunity》中，Deerhake 等人报告称，在自身免疫性神经炎症中，Dectin-1 可以通过 Card9 非依赖性上调 Oncostatin M 来促进神经保护的前馈途径。
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