Voziian P A, Kholodova Iu D, Smirnova I P, Chobot'ko G M
Vopr Med Khim. 1988 Jan-Feb;34(1):101-5.
Dimensions and density of surface charge of very low (VLDL) and low density lipoproteins (LDL) from hyman blood plasma under conditions of normal state and hypercholesterolemia were evaluated by means of radiation-free energy transition between fluorescent probes and potentiometric titration. Radia of VLDL constituted 13.9 +/- 0.6 nm and 20.7 +/- 1.2 nm and those of LDL--10.0 +/- 0.5 nm and 12 +/- 0.4 nm, respectively, in normal state and under the pathological conditions, while the density of surface charge of VLDL was equal to 0.5 X X 10(-2)K/m2 and 0.3.10(-2)K/m2; those of LDL--0.2.10(-2)K/m2 and 0.05.10(-2)K/m2, respectively. These alterations appear to facilitate the unspecific interaction between atherogenic lipoproteins and vascular cells in hypercholesterolemia.
通过荧光探针之间的无辐射能量转移和电位滴定法，评估了正常状态和高胆固醇血症条件下人血浆中极低密度脂蛋白（VLDL）和低密度脂蛋白（LDL）的表面电荷维度和密度。在正常状态和病理条件下，VLDL的半径分别为13.9±0.6纳米和20.7±1.2纳米，LDL的半径分别为10.0±0.5纳米和12±0.4纳米，而VLDL的表面电荷密度分别为0.5×10⁻²K/m²和0.3×10⁻²K/m²；LDL的表面电荷密度分别为0.2×10⁻²K/m²和0.05×10⁻²K/m²。这些变化似乎促进了高胆固醇血症中致动脉粥样硬化脂蛋白与血管细胞之间的非特异性相互作用。
