Turova N F, Misionzhnik E Iu, Ermolina L A, Aziavchik A V, Krasov V A
Vopr Med Khim. 1988 Jan-Feb;34(1):47-50.
Alterations on dynamics of excretion with urine of dopamine, noradrenaline, vanilylmandelic acid and N1-methyl nicotinamide were detected in 7-11 years old children with mental insufficiency accompanied by effective component of the hyperdynamic syndrome in the course of treatment with sidnocarb and sonapax. Sidnocarb was shown to alter positively the excretion of noradrenaline and sonapax--that of N1-methyl nicotinamide. Clinical features of the hyperdynamic syndrome should be taken into consideration in prescription of drug therapy.
在使用西多卡和索纳帕治疗过程中，发现7至11岁伴有高动力综合征有效成分的精神发育不全儿童，其尿液中多巴胺、去甲肾上腺素、香草扁桃酸和N1-甲基烟酰胺的排泄动力学发生了改变。结果显示，西多卡可使去甲肾上腺素的排泄产生积极变化，而索纳帕可使N1-甲基烟酰胺的排泄产生积极变化。在药物治疗处方中应考虑高动力综合征的临床特征。
