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[生物胺在轻度精神器质性综合征患儿智力障碍发病机制中的作用]

[Role of biogenic amines in the pathogenesis of intellectual disorders in children with minimal psychoorganic syndromes].

作者信息

Lupandin V M, Lando L I, Gromova E A, Kamenskaia V M, Zykov M B

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1978;78(10):1538-44.

PMID:716733
Abstract

Memory, attention and emotional reactivity in comparison to indices of catecholamine and serotonin metabolism were studied in 25 children from 7 to 10 years with the minimal psychoorganic syndrome during aminalon treatment. According to the excretion indices the activity equilibrium of catecholamines and serotonin were changed and were accompanied by disturbances of memory, attention and emotional reactivity. An improvement of these indices during treatment corresponded to a normalization of the activity in these systems. Questions concerning the signficance of disturbed metabolism of biogenic amines in the pathogenesis of the psychoorganic syndrome are discussed.

摘要

在氨基乙磺酸治疗期间,对25名7至10岁患有轻度精神器质性综合征的儿童,研究了其记忆力、注意力和情绪反应性,并与儿茶酚胺和血清素代谢指标进行比较。根据排泄指标,儿茶酚胺和血清素的活性平衡发生了变化,并伴有记忆力、注意力和情绪反应性的紊乱。治疗期间这些指标的改善与这些系统活性的正常化相对应。文中讨论了生物胺代谢紊乱在精神器质性综合征发病机制中的意义问题。

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