[达来argin的药代动力学] 。 （注：原文中“dalargin”可能有误，常见药物名称中无此词，推测可能是“dalargin”拼写错误，若能明确正确名称可更准确翻译）
[Pharmacokinetics of dalargin].
作者信息
Kalenikova E I, Dmitrieva O F, Korobov N V, Zhukovskiĭ S V, Tishchenko V A
出版信息
Vopr Med Khim. 1988 Jan-Feb;34(1):75-83.
Pharmacokinetics of a new anti-ulcer drug, synthetic opioid hexapeptide dalargin (Tyr-D-Ala-Gly-Phe-Leu-Arg), which is an analogue of Leu-enkephalin, was studied in rats. Distribution and metabolism of 3H-Tyr-dalargin were examined after intravenous administration at a dose of 150 mg/kg. Main Tyr-containing metabolites of dalargin were detected and dynamics of their concentrations was evaluated in blood within 1 hr after administration. Kinetic curve of dalargin was described as three-exponential function.
在大鼠中研究了一种新型抗溃疡药物——合成阿片样六肽达乐argin（酪氨酰-D-丙氨酰-甘氨酰-苯丙氨酰-亮氨酰-精氨酸）的药代动力学，它是亮氨酸脑啡肽的类似物。静脉注射剂量为150mg/kg后，检测了³H-酪氨酰-达乐argin的分布和代谢。在给药后1小时内检测了达乐argin主要含酪氨酸的代谢产物，并评估了它们在血液中的浓度动态。达乐argin的动力学曲线被描述为三指数函数。
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