Yuan L L, Mai Z J, Jiang W Z, Zhang Y L, Fan Y Y, Liu Y M
Guangzhou 12th People's Hospital, Guangzhou 510000, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2021 Feb 20;39(2):114-117. doi: 10.3760/cma.j.cn121094-20200609-00325.
To analyze the levels of T lymphocyte subsets (CD3, CD4, CD8 and CD4/CD8) in patients with paraquat poisoning, and to explore the relationship between the changes of T lymphocyte subsets and the prognosis of pulmonary fibrosis. In October 2019, a total of 47 patients with oral 20% paraquat low water solvent poisoning in Guangzhou 12th people's Hospital from June 2018 to June 2019 were selected as the research objects. Patients were divided into early death group (16 cases died within 2 weeks) and non early death group (31 cases survived more than 2 weeks) . The non early death group was divided into pulmonary fibrosis group (23 cases) and normal lung group (8 cases) . 20 healthy people in the same period were randomly selected as the control group. The neutrophils (N) , C reaction protein (CRP) , alanine aminotransferase (ALT) , creatinine (Cr) , amylase (aAMY) , creatine kinase isoenzyme (CKMB) , pH, HCO(3)(-), blood oxygen saturation (SO(2)) and lactic acid (Lac) of patients poisoned within 3 d were examined every day. Independent sample -test was used for inter group comparison, and paired sample -test was used for intra group comparison. Compared with non early death group, the levels of N, CRP, ALT, Cr, aAMY, CKMB and Lac in early death group increased (<0.05) , while pH and HCO(3)(-) decreased (<0.05) . Compared with the control group, the levels of CD3, CD4 and CD4/CD8 were decreased on the first day in the early death group and non early death group (<0.05) , and the levels of CD3, CD4 and CD4/CD8 were decreased on the 15th day in the pulmonary fibrosis group (<0.05) . Compared with the normal lung group, the levels of CD3, CD4 and CD4/CD8 in the pulmonary fibrosis group decreased on the 15th day (<0.05) . The persistent low cellular immune function in patients with paraquat poisoning is related to the progress of pulmonary fibrosis, which is an important factor affecting the prognosis of patients with pulmonary fibrosis.
分析百草枯中毒患者T淋巴细胞亚群（CD3、CD4、CD8及CD4/CD8）水平，探讨T淋巴细胞亚群变化与肺纤维化预后的关系。选取2018年6月至2019年6月在广州市第十二人民医院就诊的47例口服20%百草枯低水剂中毒患者作为研究对象。将患者分为早期死亡组（16例在2周内死亡）和非早期死亡组（31例存活超过2周）。非早期死亡组再分为肺纤维化组（23例）和正常肺组（8例）。同期随机选取20名健康人作为对照组。每天检测中毒3 d内患者的中性粒细胞（N）、C反应蛋白（CRP）、谷丙转氨酶（ALT）、肌酐（Cr）、淀粉酶（aAMY）、肌酸激酶同工酶（CKMB）、pH值、HCO(3)(-)、血氧饱和度（SO(2)）及乳酸（Lac）。组间比较采用独立样本t检验，组内比较采用配对样本t检验。与非早期死亡组比较，早期死亡组N、CRP、ALT、Cr、aAMY、CKMB及Lac水平升高（P<0.05），而pH值及HCO(3)(-)降低（P<0.05）。与对照组比较，早期死亡组和非早期死亡组第1天CD3、CD4及CD4/CD8水平降低（P<0.05），肺纤维化组第15天CD3、CD4及CD4/CD8水平降低（P<0.05）。与正常肺组比较，肺纤维化组第15天CD3、CD4及CD4/CD8水平降低（P<0.05）。百草枯中毒患者持续低细胞免疫功能与肺纤维化进展有关，是影响肺纤维化患者预后的重要因素。
