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白蛋白结合型紫杉醇治疗胰腺癌继发的黄斑囊样水肿

[Cystoid macular edema secondary to albumin-bound paclitaxel therapy for pancreatic cancer].

作者信息

Ota Shogo, Tanke Gensho, Ito Ryo, Hara Kazuya, Takada Yutaka, Adachi Kanna, Shimada Yukari, Itani Toshinao

机构信息

Department of Gastroenterology and Hepatology, Kobe City Nishi-kobe Medical Center.

出版信息

Nihon Shokakibyo Gakkai Zasshi. 2021;118(3):272-278. doi: 10.11405/nisshoshi.118.272.

Abstract

Cystoid macular edema (CME) is a rare adverse event induced by taxane-based chemotherapy. Here, we describe the case of a 71-year-old man who developed bilateral CME during treatment with nab-paclitaxel (nab-PTX) for unresectable pancreatic cancer. Two months after drug discontinuation, his vision improved, and there was significant reduction in the CME on optical coherence tomography. CME is an adverse event that can be treated with the early withdrawal of nab-PTX. Oncologists who use nab-PTX should be aware of this adverse event for timely patient referral to an ophthalmologist and appropriate treatment that would enable the preservation of the patient's visual acuity.

摘要

黄斑囊样水肿(CME)是一种由紫杉烷类化疗药物引起的罕见不良事件。在此,我们描述了一名71岁男性的病例,该患者在接受纳布紫杉醇(nab-PTX)治疗不可切除胰腺癌期间出现双侧CME。停药两个月后,他的视力有所改善,光学相干断层扫描显示CME明显减轻。CME是一种可通过早期停用nab-PTX进行治疗的不良事件。使用nab-PTX的肿瘤学家应了解这一不良事件,以便及时将患者转诊至眼科医生处,并进行适当治疗,从而能够保留患者的视力。

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