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IL4I1-driven AHR signature: a new avenue for cancer therapy.

作者信息

Wang Zuli, Li Tiansheng, Mao Chao, Liu Wenliang, Tao Yongguang

机构信息

NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.

Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China.

出版信息

Signal Transduct Target Ther. 2021 Mar 10;6(1):118. doi: 10.1038/s41392-021-00529-z.

DOI:10.1038/s41392-021-00529-z
PMID:33692337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7946875/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5de1/7946875/ad48123e22a2/41392_2021_529_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5de1/7946875/ad48123e22a2/41392_2021_529_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5de1/7946875/ad48123e22a2/41392_2021_529_Fig1_HTML.jpg

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本文引用的文献

1
IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression.IL4I1 是一种代谢免疫检查点，可激活 AHR 并促进肿瘤进展。
Cell. 2020 Sep 3;182(5):1252-1270.e34. doi: 10.1016/j.cell.2020.07.038. Epub 2020 Aug 19.
2
Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental health.犬尿氨酸：运动、炎症和心理健康中的色氨酸代谢物。
Science. 2017 Jul 28;357(6349). doi: 10.1126/science.aaf9794.
3
Aryl hydrocarbon receptor ligands in cancer: friend and foe.癌症中的芳烃受体配体：亦敌亦友
肿瘤免疫治疗中 IDO1 抑制剂的纳米递药优化：挑战与策略。
Int J Nanomedicine. 2024 Aug 28;19:8847-8882. doi: 10.2147/IJN.S458086. eCollection 2024.
4
Distinct functions of wild-type and R273H mutant Δ133p53α differentially regulate glioblastoma aggressiveness and therapy-induced senescence.野生型和 R273H 突变型 Δ133p53α 的不同功能可差异调节胶质母细胞瘤侵袭性和治疗诱导的衰老。
Cell Death Dis. 2024 Jun 27;15(6):454. doi: 10.1038/s41419-024-06769-5.
5
Immunometabolism in cancer: basic mechanisms and new targeting strategy.癌症中的免疫代谢：基本机制与新的靶向策略。
Cell Death Discov. 2024 May 16;10(1):236. doi: 10.1038/s41420-024-02006-2.
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Discov Oncol. 2024 May 1;15(1):139. doi: 10.1007/s12672-024-01000-5.
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Leukemia. 2011 Sep;25(9):1452-8. doi: 10.1038/leu.2011.111. Epub 2011 May 24.
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Human IL4I1 is a secreted L-phenylalanine oxidase expressed by mature dendritic cells that inhibits T-lymphocyte proliferation.人白细胞介素4诱导基因1产物（IL4I1）是一种由成熟树突状细胞表达的分泌型L-苯丙氨酸氧化酶，可抑制T淋巴细胞增殖。
Blood. 2007 Jul 1;110(1):220-7. doi: 10.1182/blood-2006-07-036210. Epub 2007 Mar 13.