Postgraduate Program in Medicine: Surgical Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, 90035-002, Brazil.
Surgical Oncologist and General Surgeon, Military Hospital of Porto Alegre, Porto Alegre, RS, 90440-191, Brazil.
Sci Rep. 2021 Mar 10;11(1):5574. doi: 10.1038/s41598-021-84013-2.
Acute appendicitis (AA) is the first cause of emergency surgery. Leucine-Rich Alpha-2-Glycoprotein 1 (LRG1) has been shown to be a potential biomarker in cases of AA in children, but there are conflicting results for its use in adults. The objective of this study is to compare the median plasma values of LRG1 in patients with acute abdomen with and without appendicitis. This case-control study was conducted prospectively at the emergency room (ER) of a tertiary teaching hospital, between March 1st, 2011 and December 31st, 2012. Patients with recent abdominal pain, aged 18-70 years who attended at the ER were included in the study. Blood samples were drawn at the first presentation. Those who were submitted to surgery and had a pathology report of AA were considered as cases. Those without a need for surgery and treated for other conditions, e.g., pelvic inflammatory disease, were considered as controls. Follow-up in controls was made up to 30 days. LRG1 plasma median values were measured using an ELISA kit and compared between groups. A total of 28 participants, 14 cases with acute appendicitis and 14 controls, were included. The median (range) values of leucine-rich alpha-2-glycoprotein-1 level in the group with appendicitis and control group were 8.8 ng/ml (5.5-31) and 11 (4.6-108) ng/ml, respectively (Mann-Whitney test P = 0.26). Median plasma leucine-rich alpha-2-glycoprotein-1 levels were not useful in diagnosing Acute Appendicitis in patients with acute abdominal pain.
急性阑尾炎（AA）是急诊手术的首要原因。LRG1（富含亮氨酸的α-2-糖蛋白 1）已被证明是儿童 AA 的潜在生物标志物，但在成人中的应用结果存在争议。本研究旨在比较伴或不伴阑尾炎的急性腹痛患者的 LRG1 血浆中位数。这是一项前瞻性病例对照研究，于 2011 年 3 月 1 日至 2012 年 12 月 31 日在一家三级教学医院的急诊室进行。纳入标准为年龄在 18-70 岁之间、最近有腹痛且到急诊就诊的患者。在初次就诊时抽取血样。如果患者需要手术且病理报告为急性阑尾炎，则将其视为病例。如果患者无需手术且接受其他治疗（如盆腔炎），则视为对照。对对照组进行了长达 30 天的随访。使用 ELISA 试剂盒测量 LRG1 血浆中位数，并在组间进行比较。共纳入 28 名参与者，其中 14 名病例患有急性阑尾炎，14 名对照。阑尾炎组和对照组的 LRG1 水平中位数（范围）分别为 8.8ng/ml（5.5-31）和 11ng/ml（4.6-108）（Mann-Whitney 检验 P=0.26）。急性腹痛患者的 LRG1 血浆中位数水平对诊断急性阑尾炎没有帮助。
