Zschäbitz A, Stofft E, Reichling T, Rude J, Kramer M D
Anatomisches Institut, Johannes Gutenberg-Universität Mainz.
Z Rheumatol. 1988 Jan-Feb;47(1):30-6.
Biopsy material of synovial tissue was taken from 36 patients (with arthrosis, rheumatoid arthritis, traumatic and unaffected joints). Cell and tissue cultures, as well as cells dissociated by enzymes, were investigated by light microscopy (LM), immunohistochemistry, and electron microscopy. Synovial A-cells were endowed with all morphological characteristics of phagocytic capacity but lacking the peroxidase reaction. In contrast to the monocytes, they were not immunostained by OKM-1 antibodies. The A-cells could be observed in subsequent in vitro growth for up to 2 weeks. In addition to B-cells, a third cell type was identified. This cell type had the morphological characteristics of a dendritic cell and was glass and plastic adherent. It can be referred to also as a stellate cell. We assume that these stellate cells represent modified synovial fibroblasts.
从36例患者（患有关节病、类风湿性关节炎、创伤性关节及未受影响的关节）获取滑膜组织活检材料。通过光学显微镜（LM）、免疫组织化学和电子显微镜对细胞和组织培养物以及经酶解离的细胞进行研究。滑膜A细胞具备吞噬能力的所有形态学特征，但缺乏过氧化物酶反应。与单核细胞不同，它们不能被OKM-1抗体免疫染色。A细胞在随后的体外培养中可观察到长达2周。除了B细胞外，还鉴定出第三种细胞类型。这种细胞类型具有树突状细胞的形态学特征，可贴附于玻璃和塑料表面。它也可被称为星状细胞。我们推测这些星状细胞代表经修饰的滑膜成纤维细胞。
