Alamri Fahad, Alsofayan Yousef, AlRuthia Yazed, Alahmari Ahmed, Almuzaini Yasir, Abo Gazalah Fouad, Alradini Faten, Alaama Tareef, Khan Anas
Global Center for Mass Gatherings Medicine, Ministry of Health, Riyadh, Saudi Arabia.
Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Risk Manag Healthc Policy. 2021 Mar 3;14:875-886. doi: 10.2147/RMHP.S294786. eCollection 2021.
The aim of this study was to identify the predictors of hospitalization in older (≥60 years) patients with coronavirus disease-19 (COVID-19) in Saudi Arabia.
Patients were randomly selected from a COVID-19 database maintained by the Ministry of Health, Saudi Arabia. All patients were aged ≥60 years, had reverse transcriptase-polymerase chain reaction (RT-PCR)-confirmed COVID-19, and were registered in the database during March 2020 to July 2020. Medical and sociodemographic characteristics were retrieved from the database. Additional data were collected by telephone interviews conducted by trained health professionals. Descriptive statistics and multiple logistic regression analyses were used to analyze the relationship between patient characteristics and the risk of hospitalization.
Of the 613 included patients (51.1% females), more than half (57.3%) were between 60 to 69 years of age, and 53% (324/613) had been hospitalized. The independent predictors of hospitalization included age ≥65 years (OR = 2.35, 95% CI: 1.66-3.33, < 0.001), having more than one comorbidity (OR = 1.55, 95% CI: 1.09-2.20, = 0.01), diabetes mellitus (OR = 1.52, 95% CI: 1.09-2.11, = 0.01), hypertension (OR = 1.40, 95% CI: 1.007-1.97, = 0.04), chronic kidney disease (OR = 3.87, 95% CI: 1.41-10.58, = 0.008), and history of hospital admission within the preceding year (OR = 1.69, 95% CI: 1.11-2.55, = 0.013). Risk of hospitalization was lower in males (OR = 0.65, 95% CI: 0.43-0.90, = 0.01) and in patients co-living with health care workers (OR = 0.64, 95% CI: 0.43-0.96, = 0.03).
Factors associated with higher risk of COVID-19-associated hospitalization should be used in prioritizing older adults' admission. Future studies with more robust designs should be conducted to examine the risk of COVID-19-associated illness severity and mortality.
本研究旨在确定沙特阿拉伯60岁及以上的2019冠状病毒病(COVID - 19)患者住院治疗的预测因素。
从沙特阿拉伯卫生部维护的COVID - 19数据库中随机选取患者。所有患者年龄≥60岁,经逆转录聚合酶链反应(RT - PCR)确诊为COVID - 19,并于2020年3月至2020年7月在该数据库中登记。从数据库中获取医疗和社会人口学特征。通过经过培训的卫生专业人员进行电话访谈收集额外数据。采用描述性统计和多因素逻辑回归分析来分析患者特征与住院风险之间的关系。
在纳入的613例患者中(51.1%为女性),超过一半(57.3%)年龄在60至69岁之间,53%(324/613)的患者已住院治疗。住院治疗的独立预测因素包括年龄≥65岁(比值比[OR]=2.35,95%置信区间[CI]:1.66 - 3.33,P<0.001)、患有不止一种合并症(OR = 1.55,95% CI:1.09 - 2.20,P = 0.01)、糖尿病(OR = 1.52,95% CI:1.09 - 2.11,P = 0.01)、高血压(OR = 1.40,95% CI:1.007 - 1.97,P = 0.04)、慢性肾脏病(OR = 3.87,95% CI:1.41 - 10.58,P = 0.008)以及前一年有住院史(OR = 1.69,95% CI:1.11 - 2.55,P = 0.013)。男性住院风险较低(OR = 0.65,95% CI:0.43 - 0.90,P = 0.01),与医护人员共同居住的患者住院风险也较低(OR = 0.64,95% CI:0.43 - 0.96,P = 0.03)。
与COVID - 19相关住院治疗较高风险相关的因素应用于确定老年人入院的优先顺序。应开展设计更完善的未来研究,以检查COVID - 19相关疾病严重程度和死亡率的风险。