Rheumatology Section, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University Hospital "P. Giaccone", Palermo, Italy.
Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Front Immunol. 2021 Feb 22;12:637829. doi: 10.3389/fimmu.2021.637829. eCollection 2021.
Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19) and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced by macrophages and dendritic cells, in response to exogenous or endogenous signals, and drives the differentiation and activation of T helper 17 (Th17) cells with subsequent production of IL-17A, IL-17F, IL-6, IL-22, and tumor necrosis factor α (TNF-α). Although IL-23 plays a pivotal role in the protective immune response to bacterial and fungal infections, its dysregulation has been shown to exacerbate chronic immune-mediated inflammation. Well-established experimental data support the concept that IL-23/IL-17 axis activation contributes to the development of several inflammatory diseases, such as PsA, Psoriasis, Psoriatic Arthritis; AS, Ankylosing Spondylitis; IBD, Inflammatory Bowel Disease; RA, Rheumatoid Arthritis; SS, Sjogren Syndrome; MS, Multiple Sclerosis. As a result, emerging clinical studies have focused on the blockade of this pathogenic axis as a promising therapeutic target in several autoimmune disorders; nevertheless, a greater understanding of its contribution still requires further investigation. This review aims to elucidate the most recent studies and literature data on the pathogenetic role of IL-23 and Th17 cells in inflammatory rheumatic diseases.
白细胞介素-23 (IL-23) 是一种促炎细胞因子，由两个亚基组成，IL-23A (p19) 和 IL-12/23B (p40)，后者与白细胞介素-12 (IL-12) 共享。IL-23 主要由巨噬细胞和树突状细胞在对外源或内源性信号作出反应时产生，驱动 T 辅助 17 (Th17) 细胞的分化和激活，随后产生白细胞介素-17A、白细胞介素-17F、白细胞介素-6、白细胞介素-22 和肿瘤坏死因子-α (TNF-α)。尽管 IL-23 在对细菌和真菌感染的保护性免疫反应中起着关键作用，但它的失调已被证明会加剧慢性免疫介导的炎症。成熟的实验数据支持这样一种观点，即 IL-23/IL-17 轴的激活有助于几种炎症性疾病的发展，如银屑病关节炎、银屑病、银屑病关节炎；强直性脊柱炎；炎症性肠病；类风湿关节炎；干燥综合征；多发性硬化症。因此，新兴的临床研究集中在阻断这一致病轴作为几种自身免疫性疾病的有希望的治疗靶点；然而，要更好地了解其贡献仍需要进一步的研究。这篇综述旨在阐明关于白细胞介素-23 和 Th17 细胞在炎症性风湿性疾病中的发病作用的最新研究和文献数据。
