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从[具体来源]分离出的羽扇豆宾A化合物的抗糖尿病作用：分析与分子对接研究

Anti-diabetic effect of the lupinalbin A compound isolated from : analysis and molecular docking study.

作者信息

Kim Hyo-Young, Kim Jang Hoon, Jeong Hye Gwang, Jin Chang Hyun

机构信息

Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup-si, Jeollabuk-do 56212, Republic of Korea.

College of Pharmacy, Chungnam National University, Daejeon, Chungcheongnam-do 34134, Republic of Korea.

出版信息

Biomed Rep. 2021 Apr;14(4):39. doi: 10.3892/br.2021.1415. Epub 2021 Feb 26.

DOI:10.3892/br.2021.1415
PMID:33692902
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7938295/
Abstract

Dipeptidyl peptidase 4 (DPP4) and α-glucosidase inhibitors have been developed as anti-diabetic agents for the treatment of diabetes mellitus. In the present study, the anti-diabetic effects of the lupinalbin A compound isolated from was investigated by measuring its inhibitory activity against DPP4 and α-glucosidase. To detect the inhibitory effect of lupinalbin A, DPP4 and α-glucosidase assays were performed . Molecular docking analysis was performed using AutoDock 4.2. The IC values of lupinalbin A against DPP4 and α-glucosidase were 45.2 and 53.4 µM, respectively. Analysis of the enzyme kinetics revealed that lupinalbin A interacted with the active site of DPP4 in a competitive manner, with an inhibition constant () value of 35.1±2.0 µM, whereas the lupinalbin A interaction with α-glucosidase was non-competitive, with a value of 45.0 µM. Molecular docking analysis revealed a binding pose between the DPP4 enzyme and lupinalbin A. Taken together, these data suggest lupinalbin A is more effective against DPP4 than α-glucosidase, with regard to its anti-diabetic effects.

摘要

二肽基肽酶4（DPP4）抑制剂和α-葡萄糖苷酶抑制剂已被开发用作治疗糖尿病的抗糖尿病药物。在本研究中，通过测量从[具体来源未给出]分离出的羽扇豆宾A化合物对DPP4和α-葡萄糖苷酶的抑制活性，研究了其抗糖尿病作用。为检测羽扇豆宾A的抑制作用，进行了DPP4和α-葡萄糖苷酶测定。使用AutoDock 4.2进行分子对接分析。羽扇豆宾A对DPP4和α-葡萄糖苷酶的IC值分别为45.2和53.4 μM。酶动力学分析表明，羽扇豆宾A以竞争性方式与DPP4的活性位点相互作用，抑制常数（Ki）值为35.1±2.0 μM，而羽扇豆宾A与α-葡萄糖苷酶的相互作用是非竞争性的，Ki值为45.0 μM。分子对接分析揭示了DPP4酶与羽扇豆宾A之间的结合构象。综上所述，这些数据表明，就其抗糖尿病作用而言，羽扇豆宾A对DPP4的作用比对α-葡萄糖苷酶更有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c773/7938295/4b92e04c34c2/br-14-04-01415-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c773/7938295/94ab35803c91/br-14-04-01415-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c773/7938295/10d236e3e4d6/br-14-04-01415-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c773/7938295/928a2c7ee37b/br-14-04-01415-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c773/7938295/4b92e04c34c2/br-14-04-01415-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c773/7938295/94ab35803c91/br-14-04-01415-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c773/7938295/10d236e3e4d6/br-14-04-01415-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c773/7938295/928a2c7ee37b/br-14-04-01415-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c773/7938295/4b92e04c34c2/br-14-04-01415-g03.jpg

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