Kawasoe Shin, Kubozono Takuro, Ojima Satoko, Kawabata Takeko, Miyahara Hironori, Tokushige Koichi, Ohishi Mitsuru
Department of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University Kagoshima Japan.
Kagoshima Kouseiren Hospital Kagoshima Japan.
Circ Rep. 2020 Jun 25;2(8):385-392. doi: 10.1253/circrep.CR-20-0050.
The effectiveness of weight loss (WL) in preventing blood pressure (BP) elevation is common knowledge; however, the effect of sex differences is not known. Health checkup data from Kagoshima Kouseiren Medical Healthcare Center for middle-aged participants (40-49 years old) with mild obesity (body mass index [BMI] 25.0-29.9 kg/m) who had examination data for 2 follow-up time-points (after 3 and 10 years) were analyzed. Propensity score (PS) matching using data from the first examination was used to match participants with a decrease in BMI ≥1.0 kg/m at 3 years (WL group) with those with a BMI decrease <1.0 kg/m or weight gain (non-WL group). BP values were compared after 3 and 10 years between the 2 groups, as was the prevalence of hypertension after 10 years. PS matching resulted in 232 men and 160 women in each group. Among women, systolic BP (SBP) and hypertension prevalence after 10 years were significantly lower in the WL than non-WL group (P<0.01 and P<0.05, respectively). There were no significant differences in SBP and hypertension prevalence after 10 years in men in the 2 groups. There were sex differences in the effectiveness of WL in preventing future BP elevation in mildly obese middle-aged participants: WL prevented future BP elevation and hypertension onset in women, but not in men.
体重减轻（WL）对预防血压（BP）升高的有效性是常识；然而，性别差异的影响尚不清楚。分析了鹿儿岛厚生连医疗保健中心针对轻度肥胖（体重指数[BMI]25.0 - 29.9 kg/m²）的中年参与者（40 - 49岁）的健康检查数据，这些参与者有两个随访时间点（3年和10年后）的检查数据。使用首次检查的数据进行倾向评分（PS）匹配，将3年后BMI下降≥1.0 kg/m的参与者（WL组）与BMI下降<1.0 kg/m或体重增加的参与者（非WL组）进行匹配。比较了两组在3年和10年后的BP值，以及10年后的高血压患病率。PS匹配后每组有232名男性和160名女性。在女性中，WL组10年后的收缩压（SBP）和高血压患病率显著低于非WL组（分别为P<0.01和P<0.05）。两组男性10年后的SBP和高血压患病率没有显著差异。在轻度肥胖的中年参与者中，WL预防未来BP升高的有效性存在性别差异：WL预防了女性未来的BP升高和高血压发病，但对男性没有作用。
