Fresques Tara, LaBarge Mark A
Beckman Research Institute at City of Hope, City of Hope National Medical Center, Duarte, CA USA.
Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA USA.
Aging Cancer. 2020 Dec;1(1-4):5-18. doi: 10.1002/aac2.12011. Epub 2020 Jul 3.
Yap and Taz are co-transcription factors that have been implicated in the development of many cancers. Here, we review the literature that analyzes the function of Yap/Taz in normal breast and breast cancer contexts. Our review of the literature suggests that that Yap and Taz are involved in breast cancer and Taz, in particular, is involved in the triple negative subtype. Nevertheless, the precise contexts in which Yap/Taz contribute to specific breast cancer phenotypes remains unclear. Indeed, Yap/Taz dysregulation acts differentially and in multiple epithelial cell types during early breast cancer progression. We propose Yap/Taz activation promotes breast cancer phenotypes in breast cancer precursor cells. Further, Yap dysregulation as a result of aging in breast tissue may result in microenvironments that increase the fitness of breast cancer precursor cells relative to the normal epithelia.
Yap和Taz是共同转录因子，与多种癌症的发生发展有关。在此，我们回顾了分析Yap/Taz在正常乳腺和乳腺癌背景下功能的文献。我们对文献的综述表明，Yap和Taz与乳腺癌有关，尤其是Taz与三阴性亚型有关。然而，Yap/Taz促成特定乳腺癌表型的确切背景仍不清楚。事实上，在早期乳腺癌进展过程中，Yap/Taz失调在多种上皮细胞类型中具有不同作用。我们提出，Yap/Taz激活促进乳腺癌前体细胞中的乳腺癌表型。此外，乳腺组织衰老导致的Yap失调可能会产生微环境，相对于正常上皮细胞，这种微环境会增加乳腺癌前体细胞的适应性。
