Department of Pathology, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Lab Med. 2021 Sep 1;52(5):503-508. doi: 10.1093/labmed/lmab001.
Sera from patients with multiple myeloma usually display a single monoclonal immunoglobulin band on serum protein immunofixation electrophoresis. Multiple bands may be seen if the myeloma is bi- or triclonal or if the monoclonal immunoglobulin has rheumatoid factor activity. We describe a patient with light chain-predominant IgA lambda myeloma; the patient's serum displayed 2 spatially distinct bands reacting for alpha heavy and lambda light chains. The methods used to establish monoclonality are addressed.
多发性骨髓瘤患者的血清通常在血清蛋白免疫固定电泳上显示单一的单克隆免疫球蛋白条带。如果骨髓瘤是双克隆或三克隆的，或者如果单克隆免疫球蛋白具有类风湿因子活性，则可能会看到多条带。我们描述了一位轻链为主的 IgA λ型骨髓瘤患者；患者的血清显示出 2 条空间上不同的条带，分别与 α 重链和 λ 轻链反应。用于确定单克隆性的方法也得到了探讨。
