Coffey C E, Figiel G S, Djang W T, Sullivan D C, Herfkens R J, Weiner R D
Department of Psychiatry, Duke University School of Medicine, Durham, NC 27710.
Am J Psychiatry. 1988 Jun;145(6):701-6. doi: 10.1176/ajp.145.6.701.
The authors describe a pilot prospective investigation of the effects of ECT on brain structure using magnetic resonance imaging (MRI). In nine patients with major depression, a course of ECT produced no acute changes in brain structure according to blind raters' assessments of cortical atrophy and global comparison of pre- and post-ECT studies. There were also no significant changes in the ventricle-brain ratios. Pre-ECT brain abnormalities were common in these patients yet were also unaffected by ECT. Future MRI studies of ECT should include more subjects and should address long-term changes and subtle brain abnormalities.
作者描述了一项关于电休克疗法（ECT）对脑结构影响的前瞻性初步研究，该研究使用了磁共振成像（MRI）。在9名重度抑郁症患者中，根据盲法评估者对皮质萎缩的评估以及ECT治疗前后研究的整体比较，一个疗程的ECT并未导致脑结构出现急性变化。脑室-脑比率也没有显著变化。这些患者在接受ECT治疗前脑异常情况很常见，但ECT对其也没有影响。未来关于ECT的MRI研究应纳入更多受试者，并应探讨长期变化和细微的脑异常情况。
