单侧电休克治疗期间服用苯二氮䓬类药物的患者抑郁症改善较少的证据。

Evidence for less improvement in depression in patients taking benzodiazepines during unilateral ECT.

作者信息

Pettinati H M, Stephens S M, Willis K M, Robin S E

机构信息

Research Division, Carrier Foundation, Belle Mead, NJ 08502.

出版信息

Am J Psychiatry. 1990 Aug;147(8):1029-35. doi: 10.1176/ajp.147.8.1029.

DOI:10.1176/ajp.147.8.1029

PMID:2375437

Abstract

Among 48 patients with diagnoses of depression according to DSM-III, there was a significant relation between therapeutic failure of unilateral ECT, as measured by scores on the Hamilton Rating Scale for Depression, and the concomitant use of a benzodiazepine. Of the 34 patients who showed a good therapeutic response to unilateral ECT, those taking benzodiazepines had smaller changes in their Hamilton depression ratings from before treatment to after treatment and were more symptomatic at the end of the course of ECT. Thus, when patients take benzodiazepines during a course of unilateral ECT, the maximum therapeutic response may be compromised.

摘要

在48例根据《精神疾病诊断与统计手册》第三版（DSM - III）诊断为抑郁症的患者中，以汉密尔顿抑郁量表评分衡量，单侧电休克治疗（ECT）的治疗失败与同时使用苯二氮䓬类药物之间存在显著关联。在对单侧ECT治疗反应良好的34例患者中，服用苯二氮䓬类药物的患者从治疗前到治疗后的汉密尔顿抑郁评分变化较小，且在ECT疗程结束时症状更明显。因此，当患者在单侧ECT疗程中服用苯二氮䓬类药物时，最大治疗反应可能会受到影响。