Kallikrein and antibiotics in the treatment of infertile men with genital tract infections.

A randomised group of 120 men with oligoasthenozoospermia and genital infections was investigated. All men received antibiotic treatment in a duration of 8 to 12 weeks, 64 men additionally kallikrein in a dosage of 600 units per day for a period of 3 months. No significant difference in sperm parameters could be detected between the two groups at the beginning of the study. After therapy a significant improvement was measured in sperm count as well as in percentage of motile and morphologically normal spermatozoa in either group. But in infertile men treated with antibiotics plus kallikrein improvement in sperm motility and percentage of normally shaped spermatozoa was significantly higher than in the non-kallikrein group. Pregnancy rate of 32% in the kallikrein treated group was higher than in the other group where it reached 17%. On the basis of these results we can conclude that treatment of infertile men with genital infections with antibiotics plus kallikrein is more effective than with antibiotics alone.