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[恶性肿瘤(睾丸肿瘤、恶性黑色素瘤、甲状腺癌)的生育力研究]

[Fertility studies in malignancy (tumors of the testicle, malignant melanomas, cancer of the thyroid gland)].

作者信息

Barth V, Schönfelder M

机构信息

Klinik für Nephrologie und Urologie des Bezirkskrankenhauses Aue, Karl-Marx-Universität Leipzig, GDR.

出版信息

Andrologia. 1988 Jan-Feb;20(1):75-82.

PMID:3369711
Abstract

The examination of 83 patients suffering from tumours (78 tumours of the testicle, 4 melanoblastomas, 1 carcinoma of the thyroid gland) led to conclusions on the effect of complex therapy on spermiogenesis. By means of spermiograms carried out in the course of the illness we found out restrictions of fertility which were more distinctly marked with patients suffering from gonadal tumours than with patients suffering from extragonadal tumours. The loss in ejaculation after RLN with existing tumours of the testes has to be considered as a disturbance in fertility to the highest degree. X-ray therapy impairs spermiogenesis more than chemotherapeutics. After chemotherapy we observed a recovery of spermiogenesis, after x-ray therapy only then if there were no irreversible damages of the germinal epithelium.

摘要

对83例肿瘤患者(78例睾丸肿瘤、4例成黑素细胞瘤、1例甲状腺癌)的检查得出了关于综合治疗对精子发生影响的结论。通过在病程中进行的精子图检查,我们发现生育能力受限,这在性腺肿瘤患者中比在性腺外肿瘤患者中表现得更为明显。对于患有睾丸肿瘤的患者,在施行喉返神经切除术(RLN)后射精功能丧失必须被视为最高程度的生育功能障碍。X线治疗比化疗对精子发生的损害更大。化疗后我们观察到精子发生有所恢复,而X线治疗后只有在生精上皮没有不可逆转的损害时才会恢复。

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