Bonfils P, Laccourreye H, Brasnu D, Donnadieu S, Cugnenc P H, Menard M, Fabre A, Janot F
Département d'Anesthésie-Réanimation, Groupe Hospitalier Necker Enfants-Malades, Paris.
Ann Otolaryngol Chir Cervicofac. 1988;105(2):93-6.
A series of 16 squamous cell carcinomas of the pharynx with an extension to the cervical esophagus, or multiple primaries of the pharynx and esophagus is presented. The surgical procedure consisted of an oesophagectomy associated with either total pharyngolaryngectomy, or partial pharyngectomy, or transmandibular resection. 13 patients received neo-adjuvant chemotherapy: CDDP-5-FU. Postoperative complications occurred in less than 20% without any postoperative death. One-year and five-year actuarial survival rates were respectively 20% and 13.3%. The mean survival was 9.5 +/- 3.7 months. 75% of the deaths were due to local or cervical lymph node recurrences. Neo-adjuvant chemotherapy could improve the prognosis of these pharyngo-oesophageal carcinomas.
本文报告了16例咽鳞状细胞癌侵犯颈段食管，或咽和食管多原发癌。手术方式包括食管切除术联合全喉咽切除术、部分咽切除术或经下颌骨切除术。13例患者接受了新辅助化疗：顺铂-氟尿嘧啶。术后并发症发生率低于20%，无术后死亡病例。1年和5年精算生存率分别为20%和13.3%。平均生存期为9.5±3.7个月。75%的死亡是由于局部或颈部淋巴结复发。新辅助化疗可改善这些下咽-食管癌的预后。
